Sesame effects on testicular damage in streptozotocin-induced diabetes rats

• Main Authors: Fereshteh Khaneshi, Ozra Nasrolahi, Shahriar Azizi, Vahid Nejati
• Format: Article
• Language: English
• Published: Mashhad University of Medical Sciences 2013-07-01
• Series: Avicenna Journal of Phytomedicine
• Subjects: Diabetes; Sesame; Spermatogenesis; Testis
• Online Access: http://ajp.mums.ac.ir/pdf_768_1d5893f1cebe77f0d548d04cf153810c.html

Objective(s): Reproductive dysfunction is a consequence of diabetes. Diabetes is associated with changes in testicular tissue. Sesame oil contains large amounts of polyunsaturated fatty acids and lignin with antioxidant activity, vitamin E, and monounsaturated fatty acid (MUFA). The present study investigated the effects of sesame on testis histology and male reproductive parameters in streptozotocin-induced diabetic rats. Materials and Methods: Thirty mature male Wistar rats were randomly divided into three groups, i.e., control (C), diabetic-control (DC), and sesame-treated diabetic rats (SD). Diabetes was induced by a single dose of streptozotocin (65 mg/kg; i.p). The animals were treated by a single intraperitoneal sesame extract injection (100 mg/kg b.w.) once daily for 6 weeks. Results: The biochemical analysis revealed that the diabetes resulted in significant (p