Olfactory connectivity mediates sleep-dependent food choices in humans
Sleep deprivation has marked effects on food intake, shifting food choices toward energy-dense options. Here we test the hypothesis that neural processing in central olfactory circuits, in tandem with the endocannabinoid system (ECS), plays a key role in mediating this relationship. We combined a pa...
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doaj-e33552d54da4499aaf3ab2866cf59a772021-05-05T17:59:09ZengeLife Sciences Publications LtdeLife2050-084X2019-10-01810.7554/eLife.49053Olfactory connectivity mediates sleep-dependent food choices in humansSurabhi Bhutani0James D Howard1https://orcid.org/0000-0002-9309-3773Rachel Reynolds2Phyllis C Zee3Jay Gottfried4Thorsten Kahnt5https://orcid.org/0000-0002-3575-2670Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States; School of Exercise and Nutritional Sciences, College of Health and Human Services, San Diego State University, San Diego, United StatesDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United StatesDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United StatesDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United StatesDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States; Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, United StatesDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States; Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, United States; Department of Psychology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, United StatesSleep deprivation has marked effects on food intake, shifting food choices toward energy-dense options. Here we test the hypothesis that neural processing in central olfactory circuits, in tandem with the endocannabinoid system (ECS), plays a key role in mediating this relationship. We combined a partial sleep-deprivation protocol, pattern-based olfactory neuroimaging, and ad libitum food intake to test how central olfactory mechanisms alter food intake after sleep deprivation. We found that sleep restriction increased levels of the ECS compound 2-oleoylglycerol (2-OG), enhanced encoding of food odors in piriform cortex, and shifted food choices toward energy-dense food items. Importantly, the relationship between changes in 2-OG and food choices was formally mediated by odor-evoked connectivity between the piriform cortex and insula, a region involved in integrating feeding-related signals. These findings describe a potential neurobiological pathway by which state-dependent changes in the ECS may modulate chemosensory processing to regulate food choices.https://elifesciences.org/articles/49053sleep deprivationfood intakeolfactionfMRI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Surabhi Bhutani James D Howard Rachel Reynolds Phyllis C Zee Jay Gottfried Thorsten Kahnt |
spellingShingle |
Surabhi Bhutani James D Howard Rachel Reynolds Phyllis C Zee Jay Gottfried Thorsten Kahnt Olfactory connectivity mediates sleep-dependent food choices in humans eLife sleep deprivation food intake olfaction fMRI |
author_facet |
Surabhi Bhutani James D Howard Rachel Reynolds Phyllis C Zee Jay Gottfried Thorsten Kahnt |
author_sort |
Surabhi Bhutani |
title |
Olfactory connectivity mediates sleep-dependent food choices in humans |
title_short |
Olfactory connectivity mediates sleep-dependent food choices in humans |
title_full |
Olfactory connectivity mediates sleep-dependent food choices in humans |
title_fullStr |
Olfactory connectivity mediates sleep-dependent food choices in humans |
title_full_unstemmed |
Olfactory connectivity mediates sleep-dependent food choices in humans |
title_sort |
olfactory connectivity mediates sleep-dependent food choices in humans |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2019-10-01 |
description |
Sleep deprivation has marked effects on food intake, shifting food choices toward energy-dense options. Here we test the hypothesis that neural processing in central olfactory circuits, in tandem with the endocannabinoid system (ECS), plays a key role in mediating this relationship. We combined a partial sleep-deprivation protocol, pattern-based olfactory neuroimaging, and ad libitum food intake to test how central olfactory mechanisms alter food intake after sleep deprivation. We found that sleep restriction increased levels of the ECS compound 2-oleoylglycerol (2-OG), enhanced encoding of food odors in piriform cortex, and shifted food choices toward energy-dense food items. Importantly, the relationship between changes in 2-OG and food choices was formally mediated by odor-evoked connectivity between the piriform cortex and insula, a region involved in integrating feeding-related signals. These findings describe a potential neurobiological pathway by which state-dependent changes in the ECS may modulate chemosensory processing to regulate food choices. |
topic |
sleep deprivation food intake olfaction fMRI |
url |
https://elifesciences.org/articles/49053 |
work_keys_str_mv |
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