The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD
Hypovitaminosis D is frequently present in inflammatory bowel disease (IBD) with a higher incidence in Crohn’s disease (CD) than in Ulcerative Colitis (UC). Given the involvement of the alimentary tract, many factors can contribute to hypovitaminosis D. The aim of the study was to investig...
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doaj-e335d71c1a3942b4af8b823aead350432020-11-25T02:15:41ZengMDPI AGNutrients2072-66432019-10-011111258310.3390/nu11112583nu11112583The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBDMaria Chiara Mentella0Franco Scaldaferri1Marco Pizzoferrato2Antonio Gasbarrini3Giacinto Abele Donato Miggiano4UOC di Nutrizione Clinica, Area Medicina Interna, Gastroenterologia e Oncologia Medica, Dipartimento di Scienze Gastroenterologiche, Endocrino—Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyUOC di Medicina Interna e Gastroenterologia, Area Medicina Interna, Gastroenterologia e Oncologia Medica, Dipartimento di Scienze Gastroenterologiche, Endocrino—Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyUOC di Medicina Interna e Gastroenterologia, Area Medicina Interna, Gastroenterologia e Oncologia Medica, Dipartimento di Scienze Gastroenterologiche, Endocrino—Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyUOC di Medicina Interna e Gastroenterologia, Area Medicina Interna, Gastroenterologia e Oncologia Medica, Dipartimento di Scienze Gastroenterologiche, Endocrino—Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyUOC di Nutrizione Clinica, Area Medicina Interna, Gastroenterologia e Oncologia Medica, Dipartimento di Scienze Gastroenterologiche, Endocrino—Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyHypovitaminosis D is frequently present in inflammatory bowel disease (IBD) with a higher incidence in Crohn’s disease (CD) than in Ulcerative Colitis (UC). Given the involvement of the alimentary tract, many factors can contribute to hypovitaminosis D. The aim of the study was to investigate the association of disease activity, body mass index (BMI) and phase angle with vitamin D deficiency in patients with IBD. A cross-sectional study was conducted on a cohort of 206 IBD patients (October 2016−September 2018). Of these patients, 32.6% were affected by hypovitaminosis D (CD: 38.6%; UC: 25.6%; <i>p</i> < 0.01). Negative and significant associations (<i>p</i> < 0.01) were found between BMI and vitamin D serum levels both in CD and UC patients. BMI represented a determinant of hypovitaminosis D (Odds Ratio (OR) = 1.12, <i>p</i> < 0.01) only in UC patients; phase angle was associated to hypovitaminosis D in both groups (CD: OR = 0.64, <i>p</i> < 0.05; UC: OR = 0.49, <i>p</i> < 0.01). Results of the present study confirm a higher incidence of hypovitaminosis D in patients with CD than in those with UC, and show that nutritional status plays a crucial role in the incidence of vitamin D deficiency in patients with IBD.https://www.mdpi.com/2072-6643/11/11/2583vitamin d deficiencycrohn’s diseaseulcerative colitisbmiphase angle |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Chiara Mentella Franco Scaldaferri Marco Pizzoferrato Antonio Gasbarrini Giacinto Abele Donato Miggiano |
spellingShingle |
Maria Chiara Mentella Franco Scaldaferri Marco Pizzoferrato Antonio Gasbarrini Giacinto Abele Donato Miggiano The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD Nutrients vitamin d deficiency crohn’s disease ulcerative colitis bmi phase angle |
author_facet |
Maria Chiara Mentella Franco Scaldaferri Marco Pizzoferrato Antonio Gasbarrini Giacinto Abele Donato Miggiano |
author_sort |
Maria Chiara Mentella |
title |
The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD |
title_short |
The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD |
title_full |
The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD |
title_fullStr |
The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD |
title_full_unstemmed |
The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD |
title_sort |
association of disease activity, bmi and phase angle with vitamin d deficiency in patients with ibd |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-10-01 |
description |
Hypovitaminosis D is frequently present in inflammatory bowel disease (IBD) with a higher incidence in Crohn’s disease (CD) than in Ulcerative Colitis (UC). Given the involvement of the alimentary tract, many factors can contribute to hypovitaminosis D. The aim of the study was to investigate the association of disease activity, body mass index (BMI) and phase angle with vitamin D deficiency in patients with IBD. A cross-sectional study was conducted on a cohort of 206 IBD patients (October 2016−September 2018). Of these patients, 32.6% were affected by hypovitaminosis D (CD: 38.6%; UC: 25.6%; <i>p</i> < 0.01). Negative and significant associations (<i>p</i> < 0.01) were found between BMI and vitamin D serum levels both in CD and UC patients. BMI represented a determinant of hypovitaminosis D (Odds Ratio (OR) = 1.12, <i>p</i> < 0.01) only in UC patients; phase angle was associated to hypovitaminosis D in both groups (CD: OR = 0.64, <i>p</i> < 0.05; UC: OR = 0.49, <i>p</i> < 0.01). Results of the present study confirm a higher incidence of hypovitaminosis D in patients with CD than in those with UC, and show that nutritional status plays a crucial role in the incidence of vitamin D deficiency in patients with IBD. |
topic |
vitamin d deficiency crohn’s disease ulcerative colitis bmi phase angle |
url |
https://www.mdpi.com/2072-6643/11/11/2583 |
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