Determination of dimethoxyphenethylamine derivatives in urine by deuterium labeled internal standards
The use of gas chromatography-mass spectrometry (GC-MS) in forensic analysis is increasing. To exploit fully the capabilities of MS, labeled standards, that can be used to improve the performance of the quantitative analysis, and to increase accuracy and precision, are required. A series of deuterat...
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Serbian Chemical Society
2008-01-01
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doaj-e33b49d1a54649e2985e01043a73376b2020-12-30T07:56:22ZengSerbian Chemical Society Journal of the Serbian Chemical Society0352-51391820-74212008-01-0173121223123310.2298/JSC0812223X0352-51390812223XDetermination of dimethoxyphenethylamine derivatives in urine by deuterium labeled internal standardsXu Ya-Zhu0Lin Huei-Ru1Lua Ahai-Chang2Chen Chinpiao3Department of Chemistry, National Dong Hwa University, Taiwan, R.O.C.Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, R.O.CInstitute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, R.O.C. + Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien, Taiwan, R.O.C.Department of Chemistry, National Dong Hwa University, Taiwan, R.O.CThe use of gas chromatography-mass spectrometry (GC-MS) in forensic analysis is increasing. To exploit fully the capabilities of MS, labeled standards, that can be used to improve the performance of the quantitative analysis, and to increase accuracy and precision, are required. A series of deuterated internal standards, corresponding to the 2C-series of phenethylamine derivatives, including 4-bromo-2,5-dimethoxyphenethylamine-d6 (2C-B), 4-chloro- 2,5-dimethoxyphenethylamine-d6 (2C-C), 4-iodo-2,5-dimethoxy-phenethylamine-d6 (2C-I), 4-ethylthio-2,5-dimethoxy-phenethylamine-d6 (2C-T-2) and 2,5-dimethoxy-4-n-propylthiophenethylamine-d6 (2C-T-7), were synthesized. These deuterated compounds were used to analyze for the corresponding unlabeled compounds in urine. The analysis was performed using GC-MS, with the selected ion monitoring (SIM) technique, whereby good results were achieved.http://www.doiserbia.nb.rs/img/doi/0352-5139/2008/0352-51390812223X.pdfphenethylaminedesigner drugs2c-c2c-b2c-i2c-t-22c-t-7 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xu Ya-Zhu Lin Huei-Ru Lua Ahai-Chang Chen Chinpiao |
spellingShingle |
Xu Ya-Zhu Lin Huei-Ru Lua Ahai-Chang Chen Chinpiao Determination of dimethoxyphenethylamine derivatives in urine by deuterium labeled internal standards Journal of the Serbian Chemical Society phenethylamine designer drugs 2c-c 2c-b 2c-i 2c-t-2 2c-t-7 |
author_facet |
Xu Ya-Zhu Lin Huei-Ru Lua Ahai-Chang Chen Chinpiao |
author_sort |
Xu Ya-Zhu |
title |
Determination of dimethoxyphenethylamine derivatives in urine by deuterium labeled internal standards |
title_short |
Determination of dimethoxyphenethylamine derivatives in urine by deuterium labeled internal standards |
title_full |
Determination of dimethoxyphenethylamine derivatives in urine by deuterium labeled internal standards |
title_fullStr |
Determination of dimethoxyphenethylamine derivatives in urine by deuterium labeled internal standards |
title_full_unstemmed |
Determination of dimethoxyphenethylamine derivatives in urine by deuterium labeled internal standards |
title_sort |
determination of dimethoxyphenethylamine derivatives in urine by deuterium labeled internal standards |
publisher |
Serbian Chemical Society |
series |
Journal of the Serbian Chemical Society |
issn |
0352-5139 1820-7421 |
publishDate |
2008-01-01 |
description |
The use of gas chromatography-mass spectrometry (GC-MS) in forensic analysis is increasing. To exploit fully the capabilities of MS, labeled standards, that can be used to improve the performance of the quantitative analysis, and to increase accuracy and precision, are required. A series of deuterated internal standards, corresponding to the 2C-series of phenethylamine derivatives, including 4-bromo-2,5-dimethoxyphenethylamine-d6 (2C-B), 4-chloro- 2,5-dimethoxyphenethylamine-d6 (2C-C), 4-iodo-2,5-dimethoxy-phenethylamine-d6 (2C-I), 4-ethylthio-2,5-dimethoxy-phenethylamine-d6 (2C-T-2) and 2,5-dimethoxy-4-n-propylthiophenethylamine-d6 (2C-T-7), were synthesized. These deuterated compounds were used to analyze for the corresponding unlabeled compounds in urine. The analysis was performed using GC-MS, with the selected ion monitoring (SIM) technique, whereby good results were achieved. |
topic |
phenethylamine designer drugs 2c-c 2c-b 2c-i 2c-t-2 2c-t-7 |
url |
http://www.doiserbia.nb.rs/img/doi/0352-5139/2008/0352-51390812223X.pdf |
work_keys_str_mv |
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