Involvement of epithelial-mesenchymal transition in liver fibrosis
Fibrosis of the liver is an inherent wound healing response to chronic liver injury. Regeneration of liver epithelium and restoration of normal liver structure were generally involved in this process. Although the liver has a striking capacity to adapt to damage through tissue repair, excessive accu...
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Wolters Kluwer Medknow Publications
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doaj-e34f1c2434a9469eb5b215d5b82f55aa2020-11-25T00:43:13ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492018-01-0124151110.4103/sjg.SJG_297_17Involvement of epithelial-mesenchymal transition in liver fibrosisKangkang YuQian LiGuangfeng ShiNing LiFibrosis of the liver is an inherent wound healing response to chronic liver injury. Regeneration of liver epithelium and restoration of normal liver structure were generally involved in this process. Although the liver has a striking capacity to adapt to damage through tissue repair, excessive accumulation of extracellular matrix during this process often leads to scar tissue formation and subsequent fibrosis. Epithelial to mesenchymal transition (EMT) enables a polarized epithelial cell to undergo multiple changes biochemically and to bear a mesenchymal cell phenotype. EMT plays a critical role in tissue and organ development and embryogenesis. In the liver, it is proposed that epithelial cells can acquire fibroblastic phonotype via EMT and contribute to fibrogenesis. This made EMT a potential target for antifibrotic strategies. Following an original passion, many investigators devote themselves to exploring this mechanism in liver fibrosis. However, as research continues, this hypothesis became highly controversial. The exact contribution of EMT to fibrogenesis was challenged due to the contradictory results from related studies. In this review, we summarized the recent advances regarding EMT in hepatic fibrosis and discussed the potentially involved liver cell types and pathways in order to reach rational and helpful conclusions.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=1;spage=5;epage=11;aulast=YuCholangiocyteepithelial-mesenchymal transitionhepatocytehepatic stellate cellliver fibrosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kangkang Yu Qian Li Guangfeng Shi Ning Li |
spellingShingle |
Kangkang Yu Qian Li Guangfeng Shi Ning Li Involvement of epithelial-mesenchymal transition in liver fibrosis The Saudi Journal of Gastroenterology Cholangiocyte epithelial-mesenchymal transition hepatocyte hepatic stellate cell liver fibrosis |
author_facet |
Kangkang Yu Qian Li Guangfeng Shi Ning Li |
author_sort |
Kangkang Yu |
title |
Involvement of epithelial-mesenchymal transition in liver fibrosis |
title_short |
Involvement of epithelial-mesenchymal transition in liver fibrosis |
title_full |
Involvement of epithelial-mesenchymal transition in liver fibrosis |
title_fullStr |
Involvement of epithelial-mesenchymal transition in liver fibrosis |
title_full_unstemmed |
Involvement of epithelial-mesenchymal transition in liver fibrosis |
title_sort |
involvement of epithelial-mesenchymal transition in liver fibrosis |
publisher |
Wolters Kluwer Medknow Publications |
series |
The Saudi Journal of Gastroenterology |
issn |
1319-3767 1998-4049 |
publishDate |
2018-01-01 |
description |
Fibrosis of the liver is an inherent wound healing response to chronic liver injury. Regeneration of liver epithelium and restoration of normal liver structure were generally involved in this process. Although the liver has a striking capacity to adapt to damage through tissue repair, excessive accumulation of extracellular matrix during this process often leads to scar tissue formation and subsequent fibrosis. Epithelial to mesenchymal transition (EMT) enables a polarized epithelial cell to undergo multiple changes biochemically and to bear a mesenchymal cell phenotype. EMT plays a critical role in tissue and organ development and embryogenesis. In the liver, it is proposed that epithelial cells can acquire fibroblastic phonotype via EMT and contribute to fibrogenesis. This made EMT a potential target for antifibrotic strategies. Following an original passion, many investigators devote themselves to exploring this mechanism in liver fibrosis. However, as research continues, this hypothesis became highly controversial. The exact contribution of EMT to fibrogenesis was challenged due to the contradictory results from related studies. In this review, we summarized the recent advances regarding EMT in hepatic fibrosis and discussed the potentially involved liver cell types and pathways in order to reach rational and helpful conclusions. |
topic |
Cholangiocyte epithelial-mesenchymal transition hepatocyte hepatic stellate cell liver fibrosis |
url |
http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=1;spage=5;epage=11;aulast=Yu |
work_keys_str_mv |
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1725279801531432960 |