The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults
Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with...
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doaj-e350a05de90b44e6a3137c5571ebd5212020-11-25T01:58:43ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X010.1590/1516-4446-2016-1980S1516-44462017005002103The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adultsLucas A. de AzeredoTatiana De NardiMateus L. LevandowskiSaulo G. TractenbergJulia Kommers-MolinaAndrea WieckTatiana Q. IrigarayIrênio G. da Silva FilhoRodrigo Grassi-OliveiraObjective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Methods: Eighty-seven subjects aged > 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. Results: BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). Conclusion: These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462017005002103&lng=en&tlng=enAgingbrain-derived neurotrophic factorcognitionmemorypolymorphism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lucas A. de Azeredo Tatiana De Nardi Mateus L. Levandowski Saulo G. Tractenberg Julia Kommers-Molina Andrea Wieck Tatiana Q. Irigaray Irênio G. da Silva Filho Rodrigo Grassi-Oliveira |
spellingShingle |
Lucas A. de Azeredo Tatiana De Nardi Mateus L. Levandowski Saulo G. Tractenberg Julia Kommers-Molina Andrea Wieck Tatiana Q. Irigaray Irênio G. da Silva Filho Rodrigo Grassi-Oliveira The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults Brazilian Journal of Psychiatry Aging brain-derived neurotrophic factor cognition memory polymorphism |
author_facet |
Lucas A. de Azeredo Tatiana De Nardi Mateus L. Levandowski Saulo G. Tractenberg Julia Kommers-Molina Andrea Wieck Tatiana Q. Irigaray Irênio G. da Silva Filho Rodrigo Grassi-Oliveira |
author_sort |
Lucas A. de Azeredo |
title |
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults |
title_short |
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults |
title_full |
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults |
title_fullStr |
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults |
title_full_unstemmed |
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults |
title_sort |
brain-derived neurotrophic factor (bdnf) gene val66met polymorphism affects memory performance in older adults |
publisher |
Associação Brasileira de Psiquiatria (ABP) |
series |
Brazilian Journal of Psychiatry |
issn |
1809-452X |
description |
Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Methods: Eighty-seven subjects aged > 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. Results: BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). Conclusion: These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults. |
topic |
Aging brain-derived neurotrophic factor cognition memory polymorphism |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462017005002103&lng=en&tlng=en |
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