Launching of the Anaemia Research Peruvian Cohort (ARPEC): a multicentre birth cohort project to explore the iron adaptive homeostasis, infant growth and development in three Peruvian regions
Background Preventing infantile anaemia and ensuring optimal growth and development during early childhood, particularly in resource-constrained settings, represent an ongoing public health challenge. Current responses are aligned to treatment-based solutions, instead of determining the roles of its...
Main Authors: | , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMJ Publishing Group
2021-06-01
|
Series: | BMJ Open |
Online Access: | https://bmjopen.bmj.com/content/11/5/e045609.full |
id |
doaj-e358e01850724b47b87b3327205c2ce7 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Valentina Gallo Andrew Prendergast Doreen Montag José Sanchez-Choy Carlos A Delgado Consuelo Quispe David Wareham Víctor Sánchez Ruth Anaya Elaine Flores Lorena Roca Víctor Mamani Juan Rivera Medina Pablo Velasquez Carlos Del Aguila Julio Palomino |
spellingShingle |
Valentina Gallo Andrew Prendergast Doreen Montag José Sanchez-Choy Carlos A Delgado Consuelo Quispe David Wareham Víctor Sánchez Ruth Anaya Elaine Flores Lorena Roca Víctor Mamani Juan Rivera Medina Pablo Velasquez Carlos Del Aguila Julio Palomino Launching of the Anaemia Research Peruvian Cohort (ARPEC): a multicentre birth cohort project to explore the iron adaptive homeostasis, infant growth and development in three Peruvian regions BMJ Open |
author_facet |
Valentina Gallo Andrew Prendergast Doreen Montag José Sanchez-Choy Carlos A Delgado Consuelo Quispe David Wareham Víctor Sánchez Ruth Anaya Elaine Flores Lorena Roca Víctor Mamani Juan Rivera Medina Pablo Velasquez Carlos Del Aguila Julio Palomino |
author_sort |
Valentina Gallo |
title |
Launching of the Anaemia Research Peruvian Cohort (ARPEC): a multicentre birth cohort project to explore the iron adaptive homeostasis, infant growth and development in three Peruvian regions |
title_short |
Launching of the Anaemia Research Peruvian Cohort (ARPEC): a multicentre birth cohort project to explore the iron adaptive homeostasis, infant growth and development in three Peruvian regions |
title_full |
Launching of the Anaemia Research Peruvian Cohort (ARPEC): a multicentre birth cohort project to explore the iron adaptive homeostasis, infant growth and development in three Peruvian regions |
title_fullStr |
Launching of the Anaemia Research Peruvian Cohort (ARPEC): a multicentre birth cohort project to explore the iron adaptive homeostasis, infant growth and development in three Peruvian regions |
title_full_unstemmed |
Launching of the Anaemia Research Peruvian Cohort (ARPEC): a multicentre birth cohort project to explore the iron adaptive homeostasis, infant growth and development in three Peruvian regions |
title_sort |
launching of the anaemia research peruvian cohort (arpec): a multicentre birth cohort project to explore the iron adaptive homeostasis, infant growth and development in three peruvian regions |
publisher |
BMJ Publishing Group |
series |
BMJ Open |
issn |
2044-6055 |
publishDate |
2021-06-01 |
description |
Background Preventing infantile anaemia and ensuring optimal growth and development during early childhood, particularly in resource-constrained settings, represent an ongoing public health challenge. Current responses are aligned to treatment-based solutions, instead of determining the roles of its inter-related causes. This project aims to assess and understand the complex interplay of eco-bio-social-political factors that determine infantile anaemia to inform policy, research design and prevention practices.Methods This is a longitudinal birth cohort study including four components: (1) biological, will assess known blood markers of iron homeostasis and anaemia and stool microbiota to identify and genetically analyse the participants’ flora; (2) ecological, will assess and map pollutants in air, water and soil and evaluate features of nutrition and perceived food security; (3) social, which will use different qualitative research methodologies to explore key stakeholders and informants’ perceptions related to nutritional, environmental and anaemia topics, participant observations and a participatory approach and (4) a political analysis, to identify and assess the impact of policies, guidelines and programmes at all levels for infantile anaemia in the three regions. Finally, we will also explore the role of social determinants and demographic variables longitudinally for all study participants. This project aims to contribute to the evidence of the inter-related causal factors of infantile anaemia, addressing the complexity of influencing factors from diverse methodological angles. We will assess infantile anaemia in three regions of Peru, including newborns and their mothers as participants, from childbirth until their first year of age.Ethics and dissemination Ethical approval was obtained from the Institutional Research Ethics Committee of the Instituto Nacional de Salud del Niño (Lima, Peru), CIEI-043-2019. An additional opinion has been granted by the Ethical Committee of Queen Mary University of London (London, UK). Dissemination across stakeholders is taking part as a continues part of the research process. |
url |
https://bmjopen.bmj.com/content/11/5/e045609.full |
work_keys_str_mv |
AT valentinagallo launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT andrewprendergast launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT doreenmontag launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT josesanchezchoy launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT carlosadelgado launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT consueloquispe launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT davidwareham launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT victorsanchez launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT ruthanaya launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT elaineflores launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT lorenaroca launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT victormamani launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT juanriveramedina launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT pablovelasquez launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT carlosdelaguila launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions AT juliopalomino launchingoftheanaemiaresearchperuviancohortarpecamulticentrebirthcohortprojecttoexploretheironadaptivehomeostasisinfantgrowthanddevelopmentinthreeperuvianregions |
_version_ |
1716862893865041920 |
spelling |
doaj-e358e01850724b47b87b3327205c2ce72021-09-30T16:20:23ZengBMJ Publishing GroupBMJ Open2044-60552021-06-0111510.1136/bmjopen-2020-045609Launching of the Anaemia Research Peruvian Cohort (ARPEC): a multicentre birth cohort project to explore the iron adaptive homeostasis, infant growth and development in three Peruvian regionsValentina Gallo0Andrew Prendergast1Doreen Montag2José Sanchez-Choy3Carlos A Delgado4Consuelo Quispe5David Wareham6Víctor Sánchez7Ruth Anaya8Elaine Flores9Lorena Roca10Víctor Mamani11Juan Rivera Medina12Pablo Velasquez13Carlos Del Aguila14Julio Palomino151 Centre for Primary Care and Public Health, Queen Mary University of London, London, UK1 Barts and The London School of Medicine, Queen Mary University of London, London, UKGlobal Public Health, Queen Mary University of London, London, UKDepartamento Agroforestal Agrícola, Universidad Nacional Intercultural de la Amazonia, Pucallpa, PeruResearch Group Neonatology, Department of Pediatrics, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PeruSchool of Nursing, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PeruBlizard Institute, Queen Mary University of London, London, UKDepartment of Medicine, Neonatal Intensive Care Unit, Instituto Nacional de Salud del Niño, Lima, PeruSchool of Nursing, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PeruCentre for Global Public Health, Queen Mary University of London, London, UKSchool of Nursing, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PeruExecutive Office for Research Support and Specialized Teaching, Instituto Nacional de Salud del Niño, Lima, PeruDepartment of Paediatrics, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PeruDepartment of Medicine, Neonatal Intensive Care Unit, Instituto Nacional de Salud del Niño, Lima, PeruDepartment of Medicine, Endocrinology and Metabolism Unit, Instituto Nacional de Salud del Niño, Lima, PeruFaculty of Environmental Sciences, Universidad Nacional Santiago Antúnez de Mayolo, Huaraz, PeruBackground Preventing infantile anaemia and ensuring optimal growth and development during early childhood, particularly in resource-constrained settings, represent an ongoing public health challenge. Current responses are aligned to treatment-based solutions, instead of determining the roles of its inter-related causes. This project aims to assess and understand the complex interplay of eco-bio-social-political factors that determine infantile anaemia to inform policy, research design and prevention practices.Methods This is a longitudinal birth cohort study including four components: (1) biological, will assess known blood markers of iron homeostasis and anaemia and stool microbiota to identify and genetically analyse the participants’ flora; (2) ecological, will assess and map pollutants in air, water and soil and evaluate features of nutrition and perceived food security; (3) social, which will use different qualitative research methodologies to explore key stakeholders and informants’ perceptions related to nutritional, environmental and anaemia topics, participant observations and a participatory approach and (4) a political analysis, to identify and assess the impact of policies, guidelines and programmes at all levels for infantile anaemia in the three regions. Finally, we will also explore the role of social determinants and demographic variables longitudinally for all study participants. This project aims to contribute to the evidence of the inter-related causal factors of infantile anaemia, addressing the complexity of influencing factors from diverse methodological angles. We will assess infantile anaemia in three regions of Peru, including newborns and their mothers as participants, from childbirth until their first year of age.Ethics and dissemination Ethical approval was obtained from the Institutional Research Ethics Committee of the Instituto Nacional de Salud del Niño (Lima, Peru), CIEI-043-2019. An additional opinion has been granted by the Ethical Committee of Queen Mary University of London (London, UK). Dissemination across stakeholders is taking part as a continues part of the research process.https://bmjopen.bmj.com/content/11/5/e045609.full |