Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in Vivo

The aim of this study was to investigate novel chalcones with potent angiogenic activities in vivo. Chalcone-based derivatives were evaluated using a transgenic zebrafish line with fluorescent vessels to real-time monitor the effect on angiogenesis. Results showed that the chalcone analogues did not...

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Main Authors:	Yau-Hung Chen, Chao-Yuan Chang, Chiung-Fang Chang, Po-Chih Chen, Ya-Ting Lee, Ching-Yuh Chern, Jen-Ning Tsai
Format:	Article
Language:	English
Published:	MDPI AG 2015-07-01
Series:	Molecules
Subjects:	angiogenesis chalcones in vivo zebrafish embryos
Online Access:	http://www.mdpi.com/1420-3049/20/7/12512

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record_format	Article
spelling	doaj-e361661615d54ee9be67ec5bb6a94c682020-11-24T22:01:27ZengMDPI AGMolecules1420-30492015-07-01207125121252410.3390/molecules200712512molecules200712512Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in VivoYau-Hung Chen0Chao-Yuan Chang1Chiung-Fang Chang2Po-Chih Chen3Ya-Ting Lee4Ching-Yuh Chern5Jen-Ning Tsai6Department of Chemistry, Tamkang University, 151, Ying-chuan Road, Danshui District, New Taipei City 25137, TaiwanDepartment of Chemistry, Tamkang University, 151, Ying-chuan Road, Danshui District, New Taipei City 25137, TaiwanDepartment of Life Sciences, National Chung Hsing University, Taichung 40227, TaiwanDepartment of Applied Chemistry, National Chia-Yi University, Chia-Yi 60004, TaiwanDepartment of Chemistry, Tamkang University, 151, Ying-chuan Road, Danshui District, New Taipei City 25137, TaiwanDepartment of Applied Chemistry, National Chia-Yi University, Chia-Yi 60004, TaiwanSchool of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, TaiwanThe aim of this study was to investigate novel chalcones with potent angiogenic activities in vivo. Chalcone-based derivatives were evaluated using a transgenic zebrafish line with fluorescent vessels to real-time monitor the effect on angiogenesis. Results showed that the chalcone analogues did not possess anti-angiogenic effect on zebrafish vasculatures; instead, some of them displayed potent pro-angiogenic effects on the formation of the sub-intestinal vein. Similar pro-angiogenic effects can also be seen on wild type zebrafish embryos. Moreover, the expression of vegfa, the major regulator for angiogenesis, was also upregulated in their treatment. Taken together, we have synthesized and identified a series of novel chalcone-based derivatives as potent in vivo pro-angiogenic compounds. These novel compounds hold potential for therapeutic angiogenesis.http://www.mdpi.com/1420-3049/20/7/12512angiogenesischalcones in vivozebrafish embryos
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yau-Hung Chen Chao-Yuan Chang Chiung-Fang Chang Po-Chih Chen Ya-Ting Lee Ching-Yuh Chern Jen-Ning Tsai
spellingShingle	Yau-Hung Chen Chao-Yuan Chang Chiung-Fang Chang Po-Chih Chen Ya-Ting Lee Ching-Yuh Chern Jen-Ning Tsai Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in Vivo Molecules angiogenesis chalcones in vivo zebrafish embryos
author_facet	Yau-Hung Chen Chao-Yuan Chang Chiung-Fang Chang Po-Chih Chen Ya-Ting Lee Ching-Yuh Chern Jen-Ning Tsai
author_sort	Yau-Hung Chen
title	Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in Vivo
title_short	Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in Vivo
title_full	Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in Vivo
title_fullStr	Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in Vivo
title_full_unstemmed	Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in Vivo
title_sort	pro-angiogenic effects of chalcone derivatives in zebrafish embryos in vivo
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2015-07-01
description	The aim of this study was to investigate novel chalcones with potent angiogenic activities in vivo. Chalcone-based derivatives were evaluated using a transgenic zebrafish line with fluorescent vessels to real-time monitor the effect on angiogenesis. Results showed that the chalcone analogues did not possess anti-angiogenic effect on zebrafish vasculatures; instead, some of them displayed potent pro-angiogenic effects on the formation of the sub-intestinal vein. Similar pro-angiogenic effects can also be seen on wild type zebrafish embryos. Moreover, the expression of vegfa, the major regulator for angiogenesis, was also upregulated in their treatment. Taken together, we have synthesized and identified a series of novel chalcone-based derivatives as potent in vivo pro-angiogenic compounds. These novel compounds hold potential for therapeutic angiogenesis.
topic	angiogenesis chalcones in vivo zebrafish embryos
url	http://www.mdpi.com/1420-3049/20/7/12512
work_keys_str_mv	AT yauhungchen proangiogeniceffectsofchalconederivativesinzebrafishembryosinvivo AT chaoyuanchang proangiogeniceffectsofchalconederivativesinzebrafishembryosinvivo AT chiungfangchang proangiogeniceffectsofchalconederivativesinzebrafishembryosinvivo AT pochihchen proangiogeniceffectsofchalconederivativesinzebrafishembryosinvivo AT yatinglee proangiogeniceffectsofchalconederivativesinzebrafishembryosinvivo AT chingyuhchern proangiogeniceffectsofchalconederivativesinzebrafishembryosinvivo AT jenningtsai proangiogeniceffectsofchalconederivativesinzebrafishembryosinvivo
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Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in Vivo

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