Specific TP53 subtype as biomarker for immune checkpoint inhibitors in lung adenocarcinoma
Background: Although TP53 co-mutation with KRAS/ATM/EGFR/STK11 have been proved to have predictive value for response to immune checkpoint inhibitors (ICIs), not all TP53 mutations are equal in this context. As the main part of TP53 mutant types, Missense and Nonsense alternations in TP53 as indepen...
Main Authors: | Hao Sun, Si-Yang Liu, Jia-Ying Zhou, Jin-Tian Xu, Huang-Kai Zhang, Hong-Hong Yan, Jiao-Jiao Huan, Ping-Ping Dai, Chong-Rui Xu, Jian Su, Yan-Fang Guan, Xin Yi, Rong-Shan Yu, Wen-Zhao Zhong, Yi-Long Wu |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-10-01
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Series: | EBioMedicine |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396420303662 |
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