A global lipid map defines a network essential for Zika virus replication

A global lipid map defines a network essential for Zika virus replication

Zika virus (ZIKV) remodels intracellular membranes for replication, but the role of different lipid types for infection and disease is unclear. Here, the authors perform lipidomics, show perturbation of the lipid network during ZIKV infection and show that ceramides are important for ZIKV infection.

Bibliographic Details
Main Authors: Hans C. Leier, Jules B. Weinstein, Jennifer E. Kyle, Joon-Yong Lee, Lisa M. Bramer, Kelly G. Stratton, Douglas Kempthorne, Aaron R. Navratil, Endale G. Tafesse, Thorsten Hornemann, William B. Messer, Edward A. Dennis, Thomas O. Metz, Eric Barklis, Fikadu G. Tafesse
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17433-9
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spelling doaj-e3700eeb09074ab692ee3272119631282021-07-25T11:39:45ZengNature Publishing GroupNature Communications2041-17232020-07-0111111510.1038/s41467-020-17433-9A global lipid map defines a network essential for Zika virus replicationHans C. Leier0Jules B. Weinstein1Jennifer E. Kyle2Joon-Yong Lee3Lisa M. Bramer4Kelly G. Stratton5Douglas Kempthorne6Aaron R. Navratil7Endale G. Tafesse8Thorsten Hornemann9William B. Messer10Edward A. Dennis11Thomas O. Metz12Eric Barklis13Fikadu G. Tafesse14Department of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)Department of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)Biological Sciences Division, Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL)Biological Sciences Division, Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL)Computing and Analytics Division, National Security Directorate, PNNLComputing and Analytics Division, National Security Directorate, PNNLDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)Departments of Chemistry & Biochemistry and Pharmacology, University of California San Diego School of MedicineDepartment of Plant Sciences, College of Agriculture and Bioresources, University of SaskatchewanUniversity Zurich and University Hospital Zurich, University of ZurichDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)Departments of Chemistry & Biochemistry and Pharmacology, University of California San Diego School of MedicineBiological Sciences Division, Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL)Department of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)Department of Molecular Microbiology & Immunology, Oregon Health & Science University (OHSU)Zika virus (ZIKV) remodels intracellular membranes for replication, but the role of different lipid types for infection and disease is unclear. Here, the authors perform lipidomics, show perturbation of the lipid network during ZIKV infection and show that ceramides are important for ZIKV infection.https://doi.org/10.1038/s41467-020-17433-9
collection DOAJ
language English
format Article
sources DOAJ
author Hans C. Leier
Jules B. Weinstein
Jennifer E. Kyle
Joon-Yong Lee
Lisa M. Bramer
Kelly G. Stratton
Douglas Kempthorne
Aaron R. Navratil
Endale G. Tafesse
Thorsten Hornemann
William B. Messer
Edward A. Dennis
Thomas O. Metz
Eric Barklis
Fikadu G. Tafesse
spellingShingle Hans C. Leier
Jules B. Weinstein
Jennifer E. Kyle
Joon-Yong Lee
Lisa M. Bramer
Kelly G. Stratton
Douglas Kempthorne
Aaron R. Navratil
Endale G. Tafesse
Thorsten Hornemann
William B. Messer
Edward A. Dennis
Thomas O. Metz
Eric Barklis
Fikadu G. Tafesse
A global lipid map defines a network essential for Zika virus replication
Nature Communications
author_facet Hans C. Leier
Jules B. Weinstein
Jennifer E. Kyle
Joon-Yong Lee
Lisa M. Bramer
Kelly G. Stratton
Douglas Kempthorne
Aaron R. Navratil
Endale G. Tafesse
Thorsten Hornemann
William B. Messer
Edward A. Dennis
Thomas O. Metz
Eric Barklis
Fikadu G. Tafesse
author_sort Hans C. Leier
title A global lipid map defines a network essential for Zika virus replication
title_short A global lipid map defines a network essential for Zika virus replication
title_full A global lipid map defines a network essential for Zika virus replication
title_fullStr A global lipid map defines a network essential for Zika virus replication
title_full_unstemmed A global lipid map defines a network essential for Zika virus replication
title_sort global lipid map defines a network essential for zika virus replication
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-07-01
description Zika virus (ZIKV) remodels intracellular membranes for replication, but the role of different lipid types for infection and disease is unclear. Here, the authors perform lipidomics, show perturbation of the lipid network during ZIKV infection and show that ceramides are important for ZIKV infection.
url https://doi.org/10.1038/s41467-020-17433-9
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