Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application
A series of biocompatible high-porosity (up to 72.4%) TiZr-based porous bulk metallic glass (BMG) scaffolds were successfully fabricated by hot pressing a mixture of toxic element-free TiZr-based BMG powder and an Al particle space holder. The morphology of the fabricated scaffolds was similar to th...
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doaj-e3758a1fcb0840289bed7901fade66022020-11-25T02:39:21ZengMDPI AGJournal of Functional Biomaterials2079-49832020-05-0111282810.3390/jfb11020028Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical ApplicationVan Tai Nguyen0Xavier Pei-Chun Wong1Sin-Mao Song2Pei-Hua Tsai3Jason Shian-Ching Jang4I-Yu Tsao5Che-Hsin Lin6Van Cuong Nguyen7Department of Mechanical Engineering, National Central University, Chung-Li 32001, TaiwanSchool of Biomedical Engineering, Taipei Medical University, Taipei 110, TaiwanInstitute of Materials Science and Engineering, National Central University, Chung-Li 32001, TaiwanInstitute of Materials Science and Engineering, National Central University, Chung-Li 32001, TaiwanDepartment of Mechanical Engineering, National Central University, Chung-Li 32001, TaiwanInstitute of Materials Science and Engineering, National Central University, Chung-Li 32001, TaiwanDepartment of Mechanical and Electro-Mechanical Engineering, National Sun Yat-Sen University, Kaohsiung 80424, TaiwanDepartment of Mechanical Engineering, Can Tho University, 3/2, Can Tho 900000, Viet NamA series of biocompatible high-porosity (up to 72.4%) TiZr-based porous bulk metallic glass (BMG) scaffolds were successfully fabricated by hot pressing a mixture of toxic element-free TiZr-based BMG powder and an Al particle space holder. The morphology of the fabricated scaffolds was similar to that of human bones, with pore sizes ranging from 75 to 250 μm. X-ray diffraction patterns and transmission electron microscopy images indicated that the amorphous structure of the TiZr-based BMG scaffolds remained in the amorphous state after hot pressing. Noncytotoxicity and extracellular calcium deposition of the TiZr-based BMG scaffolds at porosities of 32.8%, 48.8%, and 64.0% were examined by using the direct contact method. The results showed that the BMG scaffolds possess high cell viability and extracellular calcium deposition with average cell survival and deposition rates of approximately 170.1% and 130.9%, respectively. In addition, the resulting TiZr-based BMG scaffolds exhibited a considerable reduction in Young’s moduli from 56.4 to 2.3 GPa, compressive strength from 979 to 19 MPa, and bending strength from 157 MPa to 49 MPa when the porosity was gradually increased from 2.0% to 72.4%. Based on the aforementioned specific characteristics, TiZr-based BMG scaffolds can be considered as potential candidates for biomedical applications in the human body.https://www.mdpi.com/2079-4983/11/2/28bulk metallic glassscaffoldbiomaterialscell viabilitycalcium depositionporosity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Van Tai Nguyen Xavier Pei-Chun Wong Sin-Mao Song Pei-Hua Tsai Jason Shian-Ching Jang I-Yu Tsao Che-Hsin Lin Van Cuong Nguyen |
spellingShingle |
Van Tai Nguyen Xavier Pei-Chun Wong Sin-Mao Song Pei-Hua Tsai Jason Shian-Ching Jang I-Yu Tsao Che-Hsin Lin Van Cuong Nguyen Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application Journal of Functional Biomaterials bulk metallic glass scaffold biomaterials cell viability calcium deposition porosity |
author_facet |
Van Tai Nguyen Xavier Pei-Chun Wong Sin-Mao Song Pei-Hua Tsai Jason Shian-Ching Jang I-Yu Tsao Che-Hsin Lin Van Cuong Nguyen |
author_sort |
Van Tai Nguyen |
title |
Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application |
title_short |
Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application |
title_full |
Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application |
title_fullStr |
Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application |
title_full_unstemmed |
Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application |
title_sort |
open-cell tizr-based bulk metallic glass scaffolds with excellent biocompatibility and suitable mechanical properties for biomedical application |
publisher |
MDPI AG |
series |
Journal of Functional Biomaterials |
issn |
2079-4983 |
publishDate |
2020-05-01 |
description |
A series of biocompatible high-porosity (up to 72.4%) TiZr-based porous bulk metallic glass (BMG) scaffolds were successfully fabricated by hot pressing a mixture of toxic element-free TiZr-based BMG powder and an Al particle space holder. The morphology of the fabricated scaffolds was similar to that of human bones, with pore sizes ranging from 75 to 250 μm. X-ray diffraction patterns and transmission electron microscopy images indicated that the amorphous structure of the TiZr-based BMG scaffolds remained in the amorphous state after hot pressing. Noncytotoxicity and extracellular calcium deposition of the TiZr-based BMG scaffolds at porosities of 32.8%, 48.8%, and 64.0% were examined by using the direct contact method. The results showed that the BMG scaffolds possess high cell viability and extracellular calcium deposition with average cell survival and deposition rates of approximately 170.1% and 130.9%, respectively. In addition, the resulting TiZr-based BMG scaffolds exhibited a considerable reduction in Young’s moduli from 56.4 to 2.3 GPa, compressive strength from 979 to 19 MPa, and bending strength from 157 MPa to 49 MPa when the porosity was gradually increased from 2.0% to 72.4%. Based on the aforementioned specific characteristics, TiZr-based BMG scaffolds can be considered as potential candidates for biomedical applications in the human body. |
topic |
bulk metallic glass scaffold biomaterials cell viability calcium deposition porosity |
url |
https://www.mdpi.com/2079-4983/11/2/28 |
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