Adenosquamous Carcinoma of the Choledochus

• Main Authors: Daisuke Uehara, Hitoshi Takagi, Takashi Hoshino, Yuhei Suzuki, Satoshi Takakusagi, Kyoko Maruhashi, Kazuko Kizawa, Takashi Kosone, Atsushi Naganuma, Etsuko Hisanaga, Junko Hirato, Satoru Kakizaki, Toshio Uraoka
• Format: Article
• Language: English
• Published: Karger Publishers 2019-01-01
• Series: Case Reports in Gastroenterology
• Subjects: Adenosquamous carcinoma; Choledochus cancer
• Online Access: https://www.karger.com/Article/FullText/495936
• ISSN: 1662-0631

The patient was an 86-year-old man who was admitted with obstructive jaundice. Computed tomography revealed a tumor in the hilar choledochus with peripheral hepatic duct dilatation. Endoscopic cholangiography (ERC) demonstrated the defect in the choledochus. Brushing cytology during ERC showed Orange-G-philic keratinized atypical cells, which led to a diagnosis of squamous cell carcinoma. Chemotherapy with tegafur-gimeracil-oteracil potassium was ineffective and was discontinued due to adverse effects. The patient died 5 months after the diagnosis and autopsy revealed tubular adenocarcinoma of the hilar bile duct with squamous cell carcinoma component. Progression of the disease might influence the distribution of adenosquamous carcinoma. The clinicopathological sequence of adenosquamous carcinoma of the choledochus was documented.