MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population
Recently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding miRNAs and daily alcohol consu...
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doaj-e390685111234ea4878e0ea2fee780752020-11-24T21:17:56ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-08-01178133810.3390/ijms17081338ijms17081338MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean PopulationRocío Barragán0Oscar Coltell1Eva M. Asensio2Francesc Francés3José V. Sorlí4Ramon Estruch5Albert Salas-Huetos6Jose M. Ordovas7Dolores Corella8Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia 46010, SpainCIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid 28029, SpainDepartment of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia 46010, SpainDepartment of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia 46010, SpainDepartment of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia 46010, SpainCIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid 28029, SpainCIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid 28029, SpainDepartment of Cardiovascular Epidemiology and Population Genetics, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, SpainDepartment of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia 46010, SpainRecently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding miRNAs and daily alcohol consumption at the population level. Our aim was to investigate the association between a functional polymorphism in the pre-miR-27a (rs895819 A>G) gene and alcohol consumption in an elderly population. We undertook a cross-sectional study of PREvención con DIeta MEDiterránea (PREDIMED)-Valencia participants (n = 1007, including men and women aged 67 ± 7 years) and measured their alcohol consumption (total and alcoholic beverages) through a validated questionnaire. We found a strong association between the pre-miR-27a polymorphism and total alcohol intake, this being higher in GG subjects (5.2 ± 0.4 in AA, 5.9 ± 0.5 in AG and 9.1 ± 1.8 g/day in GG; padjusted = 0.019). We also found a statistically-significant association of the pre-miR-27a polymorphism with the risk of having a high alcohol intake (>2 drinks/day in men and >1 in women): 5.9% in AA versus 17.5% in GG; padjusted < 0.001. In the sensitivity analysis, this association was homogeneous for sex, obesity and Mediterranean diet adherence. In conclusion, we report for the first time a significant association between a miRNA polymorphism (rs895819) and daily alcohol consumption.http://www.mdpi.com/1422-0067/17/8/1338microRNAsalcoholmiR27aMediterranean |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rocío Barragán Oscar Coltell Eva M. Asensio Francesc Francés José V. Sorlí Ramon Estruch Albert Salas-Huetos Jose M. Ordovas Dolores Corella |
spellingShingle |
Rocío Barragán Oscar Coltell Eva M. Asensio Francesc Francés José V. Sorlí Ramon Estruch Albert Salas-Huetos Jose M. Ordovas Dolores Corella MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population International Journal of Molecular Sciences microRNAs alcohol miR27a Mediterranean |
author_facet |
Rocío Barragán Oscar Coltell Eva M. Asensio Francesc Francés José V. Sorlí Ramon Estruch Albert Salas-Huetos Jose M. Ordovas Dolores Corella |
author_sort |
Rocío Barragán |
title |
MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population |
title_short |
MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population |
title_full |
MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population |
title_fullStr |
MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population |
title_full_unstemmed |
MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population |
title_sort |
micrornas and drinking: association between the pre-mir-27a rs895819 polymorphism and alcohol consumption in a mediterranean population |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2016-08-01 |
description |
Recently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding miRNAs and daily alcohol consumption at the population level. Our aim was to investigate the association between a functional polymorphism in the pre-miR-27a (rs895819 A>G) gene and alcohol consumption in an elderly population. We undertook a cross-sectional study of PREvención con DIeta MEDiterránea (PREDIMED)-Valencia participants (n = 1007, including men and women aged 67 ± 7 years) and measured their alcohol consumption (total and alcoholic beverages) through a validated questionnaire. We found a strong association between the pre-miR-27a polymorphism and total alcohol intake, this being higher in GG subjects (5.2 ± 0.4 in AA, 5.9 ± 0.5 in AG and 9.1 ± 1.8 g/day in GG; padjusted = 0.019). We also found a statistically-significant association of the pre-miR-27a polymorphism with the risk of having a high alcohol intake (>2 drinks/day in men and >1 in women): 5.9% in AA versus 17.5% in GG; padjusted < 0.001. In the sensitivity analysis, this association was homogeneous for sex, obesity and Mediterranean diet adherence. In conclusion, we report for the first time a significant association between a miRNA polymorphism (rs895819) and daily alcohol consumption. |
topic |
microRNAs alcohol miR27a Mediterranean |
url |
http://www.mdpi.com/1422-0067/17/8/1338 |
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