Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery
Nur Akma Abdul Halim,1 Mohd Zobir Hussein,1 Mohd Khairuddin Kandar2 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, Seri Kembangan, Selangor Darul Ehsan, 43400, Malaysia; 2Department of Orthopedics, Faculty of Medicine and Health Sciences, Universiti Putra Mal...
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doaj-e397ac1dec1147f1888fbc1208f2528a2021-10-02T19:24:04ZengDove Medical PressInternational Journal of Nanomedicine1178-20132021-09-01Volume 166477649669066Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug DeliveryAbdul Halim NAHussein MZKandar MKNur Akma Abdul Halim,1 Mohd Zobir Hussein,1 Mohd Khairuddin Kandar2 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, Seri Kembangan, Selangor Darul Ehsan, 43400, Malaysia; 2Department of Orthopedics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Selangor Darul Ehsan, 43400, MalaysiaCorrespondence: Mohd Zobir Hussein Email mzobir@upm.edu.myAbstract: Hydroxyapatite is a basic mineral that is very important to the human body framework. Recently, synthetic hydroxyapatite (SHA) and its nanocomposites (HANs) are the subject of intense research for bone tissue engineering and drug loading system applications, due to their unique, tailor-made characteristics, as well as their similarities with the bone mineral component in the human body. Although hydroxyapatite has good biocompatibility and osteoconductive characteristics, the poor mechanical strength restricts its use in non-load-bearing applications. Consequently, a rapid increase in reinforcing of other nanomaterials into hydroxyapatite for the formation of HANs could improve the mechanical properties. Most of the research reported on the success of other nanomaterials such as metals, ceramics and natural/synthetic polymers as additions into hydroxyapatite is reviewed. In addition, this review also focuses on the addition of various substances into hydroxyapatite for the formation of various HANs and at the same time to try to minimize the limitations so that various bone tissue engineering and drug loading system applications can be exploited.Keywords: hydroxyapatite, nanocomposites, physicochemical enhancement, bone tissue engineering and drug carrierhttps://www.dovepress.com/nanomaterials-upconverted-hydroxyapatite-for-bone-tissue-engineering-a-peer-reviewed-fulltext-article-IJNhydroxyapatitenanocompositesphysicochemical enhancementbone tissue engineering and drug carrier |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abdul Halim NA Hussein MZ Kandar MK |
spellingShingle |
Abdul Halim NA Hussein MZ Kandar MK Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery International Journal of Nanomedicine hydroxyapatite nanocomposites physicochemical enhancement bone tissue engineering and drug carrier |
author_facet |
Abdul Halim NA Hussein MZ Kandar MK |
author_sort |
Abdul Halim NA |
title |
Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery |
title_short |
Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery |
title_full |
Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery |
title_fullStr |
Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery |
title_full_unstemmed |
Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery |
title_sort |
nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery |
publisher |
Dove Medical Press |
series |
International Journal of Nanomedicine |
issn |
1178-2013 |
publishDate |
2021-09-01 |
description |
Nur Akma Abdul Halim,1 Mohd Zobir Hussein,1 Mohd Khairuddin Kandar2 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, Seri Kembangan, Selangor Darul Ehsan, 43400, Malaysia; 2Department of Orthopedics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Selangor Darul Ehsan, 43400, MalaysiaCorrespondence: Mohd Zobir Hussein Email mzobir@upm.edu.myAbstract: Hydroxyapatite is a basic mineral that is very important to the human body framework. Recently, synthetic hydroxyapatite (SHA) and its nanocomposites (HANs) are the subject of intense research for bone tissue engineering and drug loading system applications, due to their unique, tailor-made characteristics, as well as their similarities with the bone mineral component in the human body. Although hydroxyapatite has good biocompatibility and osteoconductive characteristics, the poor mechanical strength restricts its use in non-load-bearing applications. Consequently, a rapid increase in reinforcing of other nanomaterials into hydroxyapatite for the formation of HANs could improve the mechanical properties. Most of the research reported on the success of other nanomaterials such as metals, ceramics and natural/synthetic polymers as additions into hydroxyapatite is reviewed. In addition, this review also focuses on the addition of various substances into hydroxyapatite for the formation of various HANs and at the same time to try to minimize the limitations so that various bone tissue engineering and drug loading system applications can be exploited.Keywords: hydroxyapatite, nanocomposites, physicochemical enhancement, bone tissue engineering and drug carrier |
topic |
hydroxyapatite nanocomposites physicochemical enhancement bone tissue engineering and drug carrier |
url |
https://www.dovepress.com/nanomaterials-upconverted-hydroxyapatite-for-bone-tissue-engineering-a-peer-reviewed-fulltext-article-IJN |
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