Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic
Editorial summary Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major...
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BMC
2017-09-01
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| Series: | Genome Medicine |
| Online Access: | http://link.springer.com/article/10.1186/s13073-017-0475-4 |
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doaj-e39900d4e4ea4a7687362aae20d66d352020-11-24T21:47:18ZengBMCGenome Medicine1756-994X2017-09-01911410.1186/s13073-017-0475-4Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinicDianne Nicol0Lisa Eckstein1Michael Morrison2Jacob S. Sherkow3Margaret Otlowski4Tess Whitton5Tania Bubela6Kathryn P. Burdon7Don Chalmers8Sarah Chan9Jac Charlesworth10Christine Critchley11Merlin Crossley12Sheryl de Lacey13Joanne L. Dickinson14Alex W. Hewitt15Joanne Kamens16Kazuto Kato17Erika Kleiderman18Satoshi Kodama19John Liddicoat20David A. Mackey21Ainsley J. Newson22Jane Nielsen23Jennifer K. Wagner24Rebekah E. McWhirter25Centre for Law and Genetics, Faculty of Law, University of TasmaniaCentre for Law and Genetics, Faculty of Law, University of TasmaniaCentre for Health, Law and Emerging Technologies, Nuffield Department of Population Health, University of OxfordInnovation Center for Law and Technology, New York Law SchoolCentre for Law and Genetics, Faculty of Law, University of TasmaniaCentre for Law and Genetics, Faculty of Law, University of TasmaniaFaculty of Health Sciences, Simon Fraser UniversityMenzies Institute for Medical Research, University of TasmaniaCentre for Law and Genetics, Faculty of Law, University of TasmaniaUsher Institute for Population Health Sciences and Informatics, University of EdinburghMenzies Institute for Medical Research, University of TasmaniaDepartment of Statistics, Data Science and Epidemiology, Swinburne University of TechnologySchool of Biotechnology and Biomolecular Sciences, University of New South WalesSchool of Nursing and Midwifery, Flinders UniversityMenzies Institute for Medical Research, University of TasmaniaMenzies Institute for Medical Research, University of TasmaniaAddgeneDepartment of Biomedical Ethics and Public Policy, Graduate School of Medicine, Osaka UniversityCentre of Genomics and Policy, Department of Human Genetics, McGill UniversityDepartment of Ethic, Graduate School of Letters, Kyoto UniversityFaculty of Law, University of CambridgeCentre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye InstituteSydney Health Ethics, Sydney School of Public Health, University of SydneyCentre for Law and Genetics, Faculty of Law, University of TasmaniaCenter for Translational Bioethics & Health Care Policy, Geisinger Health SystemCentre for Law and Genetics, Faculty of Law, University of TasmaniaEditorial summary Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy.http://link.springer.com/article/10.1186/s13073-017-0475-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Dianne Nicol Lisa Eckstein Michael Morrison Jacob S. Sherkow Margaret Otlowski Tess Whitton Tania Bubela Kathryn P. Burdon Don Chalmers Sarah Chan Jac Charlesworth Christine Critchley Merlin Crossley Sheryl de Lacey Joanne L. Dickinson Alex W. Hewitt Joanne Kamens Kazuto Kato Erika Kleiderman Satoshi Kodama John Liddicoat David A. Mackey Ainsley J. Newson Jane Nielsen Jennifer K. Wagner Rebekah E. McWhirter |
| spellingShingle |
Dianne Nicol Lisa Eckstein Michael Morrison Jacob S. Sherkow Margaret Otlowski Tess Whitton Tania Bubela Kathryn P. Burdon Don Chalmers Sarah Chan Jac Charlesworth Christine Critchley Merlin Crossley Sheryl de Lacey Joanne L. Dickinson Alex W. Hewitt Joanne Kamens Kazuto Kato Erika Kleiderman Satoshi Kodama John Liddicoat David A. Mackey Ainsley J. Newson Jane Nielsen Jennifer K. Wagner Rebekah E. McWhirter Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic Genome Medicine |
| author_facet |
Dianne Nicol Lisa Eckstein Michael Morrison Jacob S. Sherkow Margaret Otlowski Tess Whitton Tania Bubela Kathryn P. Burdon Don Chalmers Sarah Chan Jac Charlesworth Christine Critchley Merlin Crossley Sheryl de Lacey Joanne L. Dickinson Alex W. Hewitt Joanne Kamens Kazuto Kato Erika Kleiderman Satoshi Kodama John Liddicoat David A. Mackey Ainsley J. Newson Jane Nielsen Jennifer K. Wagner Rebekah E. McWhirter |
| author_sort |
Dianne Nicol |
| title |
Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_short |
Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_full |
Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_fullStr |
Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_full_unstemmed |
Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_sort |
key challenges in bringing crispr-mediated somatic cell therapy into the clinic |
| publisher |
BMC |
| series |
Genome Medicine |
| issn |
1756-994X |
| publishDate |
2017-09-01 |
| description |
Editorial summary Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy. |
| url |
http://link.springer.com/article/10.1186/s13073-017-0475-4 |
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