High fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalus

High fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalus

A possible relationship between fibrosis along the route of cerebrospinal fluid (CSF) flow and the subsequent development of hydrocephalus has been indicated in previous studies. These changes in the fibrosis index may reflect the severity of hydrocephalus and could potentially become a diagnostic t...

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Bibliographic Details
Main Authors: Hao Xu, Junwen Wang, Jiaqing Li, Ran Li, Zhuo Zhang, Yimin Huang, Wei Jiao, Wei Sun, Ting Lei
Format: Article
Language:English
Published: De Gruyter 2016-01-01
Series:Translational Neuroscience
Subjects:
fibrosis
hyaluronic acid
hydrocephalus
laminin
procollagen
tgf-β1
Online Access:https://doi.org/10.1515/tnsci-2016-0015
Description
Summary:A possible relationship between fibrosis along the route of cerebrospinal fluid (CSF) flow and the subsequent development of hydrocephalus has been indicated in previous studies. These changes in the fibrosis index may reflect the severity of hydrocephalus and could potentially become a diagnostic tool. The object of this study was to analyze the levels of procollagen type I C-terminal propeptide (PICP), procollagen type III N-terminal propeptide (PIIINP), hyaluronic acid (HA), and laminin (LN) in the CSF of patients with post-traumatic hydrocephalus and determine the significance of their presence.
ISSN:2081-6936

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