High fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalus

A possible relationship between fibrosis along the route of cerebrospinal fluid (CSF) flow and the subsequent development of hydrocephalus has been indicated in previous studies. These changes in the fibrosis index may reflect the severity of hydrocephalus and could potentially become a diagnostic t...

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Main Authors:	Hao Xu, Junwen Wang, Jiaqing Li, Ran Li, Zhuo Zhang, Yimin Huang, Wei Jiao, Wei Sun, Ting Lei
Format:	Article
Language:	English
Published:	De Gruyter 2016-01-01
Series:	Translational Neuroscience
Subjects:	fibrosis hyaluronic acid hydrocephalus laminin procollagen tgf-β1
Online Access:	https://doi.org/10.1515/tnsci-2016-0015

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spelling	doaj-e39b64096ea44500b916f391e5f614b72021-09-05T20:51:30ZengDe GruyterTranslational Neuroscience2081-69362016-01-0171929710.1515/tnsci-2016-0015tnsci-2016-0015High fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalusHao Xu0Junwen Wang1Jiaqing Li2Ran Li3Zhuo Zhang4Yimin Huang5Wei Jiao6Wei Sun7Ting Lei8Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. ChinaA possible relationship between fibrosis along the route of cerebrospinal fluid (CSF) flow and the subsequent development of hydrocephalus has been indicated in previous studies. These changes in the fibrosis index may reflect the severity of hydrocephalus and could potentially become a diagnostic tool. The object of this study was to analyze the levels of procollagen type I C-terminal propeptide (PICP), procollagen type III N-terminal propeptide (PIIINP), hyaluronic acid (HA), and laminin (LN) in the CSF of patients with post-traumatic hydrocephalus and determine the significance of their presence.https://doi.org/10.1515/tnsci-2016-0015fibrosishyaluronic acidhydrocephaluslamininprocollagentgf-β1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hao Xu Junwen Wang Jiaqing Li Ran Li Zhuo Zhang Yimin Huang Wei Jiao Wei Sun Ting Lei
spellingShingle	Hao Xu Junwen Wang Jiaqing Li Ran Li Zhuo Zhang Yimin Huang Wei Jiao Wei Sun Ting Lei High fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalus Translational Neuroscience fibrosis hyaluronic acid hydrocephalus laminin procollagen tgf-β1
author_facet	Hao Xu Junwen Wang Jiaqing Li Ran Li Zhuo Zhang Yimin Huang Wei Jiao Wei Sun Ting Lei
author_sort	Hao Xu
title	High fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalus
title_short	High fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalus
title_full	High fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalus
title_fullStr	High fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalus
title_full_unstemmed	High fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalus
title_sort	high fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalus
publisher	De Gruyter
series	Translational Neuroscience
issn	2081-6936
publishDate	2016-01-01
description	A possible relationship between fibrosis along the route of cerebrospinal fluid (CSF) flow and the subsequent development of hydrocephalus has been indicated in previous studies. These changes in the fibrosis index may reflect the severity of hydrocephalus and could potentially become a diagnostic tool. The object of this study was to analyze the levels of procollagen type I C-terminal propeptide (PICP), procollagen type III N-terminal propeptide (PIIINP), hyaluronic acid (HA), and laminin (LN) in the CSF of patients with post-traumatic hydrocephalus and determine the significance of their presence.
topic	fibrosis hyaluronic acid hydrocephalus laminin procollagen tgf-β1
url	https://doi.org/10.1515/tnsci-2016-0015
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High fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalus

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