Assessment of Salivary Gland Function Using Salivary Scintigraphy in Pre and Post Radioactive Iodine Therapy in Diagnosed Thyroid Carcinoma Patients
Introduction: Thyroid carcinoma represents less than 1% of all cancers. The first line of treatment for thyroid cancer is partial/ total thyroidectomy. High-dose Iodine131 therapy using Iodine radioisotopes is commonly used in patients with well differentiated thyroid carcinoma after total thyro...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2016-01-01
|
Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/7121/16091_CE(RA1)_F(T)_PF1(Ek_Om)_PFA(AK)_PF2(PAG).pdf |
id |
doaj-e3a476cb68284c388e9483fe88e208aa |
---|---|
record_format |
Article |
spelling |
doaj-e3a476cb68284c388e9483fe88e208aa2020-11-25T03:53:09ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-01-01101ZC60ZC6210.7860/JCDR/2016/16091.7121Assessment of Salivary Gland Function Using Salivary Scintigraphy in Pre and Post Radioactive Iodine Therapy in Diagnosed Thyroid Carcinoma PatientsRaj Kumar Badam0Jyotsna Suram1Dara Balaji Gandhi Babu2Shefali Waghray3Rahul Marshal4Sharath Chandra Bontha5Reddy Lavanya6Sudheer Kanth7Reader, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences, Hyderabad, India.Senior Lecturer, Department of Oral Medicine & Radiology, Shadan Dental College, Hyderabad, India.Professor and Head of Department, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences, Hyderabad, India.Senior Lecturer, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences, Hyderabad, India.Reader, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences, Hyderabad, India.Professor, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences, Hyderabad, India.Senior Lecturer, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences, Hyderabad, India.Reader, Department of Oral & Maxillofacial Pathology, Mamatha Dental College, Khammam, Telangana State, India.Introduction: Thyroid carcinoma represents less than 1% of all cancers. The first line of treatment for thyroid cancer is partial/ total thyroidectomy. High-dose Iodine131 therapy using Iodine radioisotopes is commonly used in patients with well differentiated thyroid carcinoma after total thyroidectomy. In this process, the non-thyroidal tissues, such as, salivary gland, stomach and breast tissues also take up radioactive iodine. Salivary gland scintigraphy is widely accepted as a sensitive and valid method for evaluation of salivary gland dysfunction after Radioactive Iodine131 Therapy (RIT). Aim: To assess and compare the salivary flow rates, relative uptake and ejection fractions in parotid and submandibular glands just before and one month after Iodine131 therapy. Materials and Methods: The study was conducted on 24 patients diagnosed with well differentiated thyroid carcinoma who underwent partial/total thyroidectomy and were due for radioactive iodine therapy. These patients were divided into two groups based on the lesion based dosimetry (Group A: 60-100Gy; Group B: 100- 150Gy). Salivary gland assessment was done by salivary gland scintigraphy before and after RIT. Statistical Analysis: The data collected was tabulated and statistically analysed using SPSS software version16 using paired t-test and individual sample t-test. Results: A statistically significant difference in the uptake percent and ejection fraction percent in the parotid and submandibular glands before RIT and one month after RIT was observed in the study. Conclusion: We inferred from the study that there was an overall decrease in uptake percent and ejection fraction percent one month post RIT in both parotid and submandibular glands. Also, a statistically significant difference was noted in the uptake and ejection fraction percent between Group A and Group B concluding the fact that the damage is dose related. https://jcdr.net/articles/PDF/7121/16091_CE(RA1)_F(T)_PF1(Ek_Om)_PFA(AK)_PF2(PAG).pdfradionuclide imagingradioisotopesxerostomia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Raj Kumar Badam Jyotsna Suram Dara Balaji Gandhi Babu Shefali Waghray Rahul Marshal Sharath Chandra Bontha Reddy Lavanya Sudheer Kanth |
spellingShingle |
Raj Kumar Badam Jyotsna Suram Dara Balaji Gandhi Babu Shefali Waghray Rahul Marshal Sharath Chandra Bontha Reddy Lavanya Sudheer Kanth Assessment of Salivary Gland Function Using Salivary Scintigraphy in Pre and Post Radioactive Iodine Therapy in Diagnosed Thyroid Carcinoma Patients Journal of Clinical and Diagnostic Research radionuclide imaging radioisotopes xerostomia |
author_facet |
Raj Kumar Badam Jyotsna Suram Dara Balaji Gandhi Babu Shefali Waghray Rahul Marshal Sharath Chandra Bontha Reddy Lavanya Sudheer Kanth |
author_sort |
Raj Kumar Badam |
title |
Assessment of Salivary Gland Function Using Salivary Scintigraphy in Pre and Post Radioactive Iodine Therapy in Diagnosed Thyroid Carcinoma Patients |
title_short |
Assessment of Salivary Gland Function Using Salivary Scintigraphy in Pre and Post Radioactive Iodine Therapy in Diagnosed Thyroid Carcinoma Patients |
title_full |
Assessment of Salivary Gland Function Using Salivary Scintigraphy in Pre and Post Radioactive Iodine Therapy in Diagnosed Thyroid Carcinoma Patients |
title_fullStr |
Assessment of Salivary Gland Function Using Salivary Scintigraphy in Pre and Post Radioactive Iodine Therapy in Diagnosed Thyroid Carcinoma Patients |
title_full_unstemmed |
Assessment of Salivary Gland Function Using Salivary Scintigraphy in Pre and Post Radioactive Iodine Therapy in Diagnosed Thyroid Carcinoma Patients |
title_sort |
assessment of salivary gland function using salivary scintigraphy in pre and post radioactive iodine therapy in diagnosed thyroid carcinoma patients |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2016-01-01 |
description |
Introduction: Thyroid carcinoma represents less than 1% of all
cancers. The first line of treatment for thyroid cancer is partial/
total thyroidectomy. High-dose Iodine131 therapy using Iodine
radioisotopes is commonly used in patients with well differentiated
thyroid carcinoma after total thyroidectomy. In this process, the
non-thyroidal tissues, such as, salivary gland, stomach and breast
tissues also take up radioactive iodine. Salivary gland scintigraphy
is widely accepted as a sensitive and valid method for evaluation
of salivary gland dysfunction after Radioactive Iodine131 Therapy
(RIT).
Aim: To assess and compare the salivary flow rates, relative
uptake and ejection fractions in parotid and submandibular glands
just before and one month after Iodine131 therapy.
Materials and Methods: The study was conducted on 24
patients diagnosed with well differentiated thyroid carcinoma who
underwent partial/total thyroidectomy and were due for radioactive
iodine therapy. These patients were divided into two groups based
on the lesion based dosimetry (Group A: 60-100Gy; Group B: 100-
150Gy). Salivary gland assessment was done by salivary gland
scintigraphy before and after RIT.
Statistical Analysis: The data collected was tabulated and
statistically analysed using SPSS software version16 using paired
t-test and individual sample t-test.
Results: A statistically significant difference in the uptake percent
and ejection fraction percent in the parotid and submandibular
glands before RIT and one month after RIT was observed in the
study.
Conclusion: We inferred from the study that there was an overall
decrease in uptake percent and ejection fraction percent one
month post RIT in both parotid and submandibular glands. Also,
a statistically significant difference was noted in the uptake and
ejection fraction percent between Group A and Group B concluding
the fact that the damage is dose related.
|
topic |
radionuclide imaging radioisotopes xerostomia |
url |
https://jcdr.net/articles/PDF/7121/16091_CE(RA1)_F(T)_PF1(Ek_Om)_PFA(AK)_PF2(PAG).pdf |
work_keys_str_mv |
AT rajkumarbadam assessmentofsalivaryglandfunctionusingsalivaryscintigraphyinpreandpostradioactiveiodinetherapyindiagnosedthyroidcarcinomapatients AT jyotsnasuram assessmentofsalivaryglandfunctionusingsalivaryscintigraphyinpreandpostradioactiveiodinetherapyindiagnosedthyroidcarcinomapatients AT darabalajigandhibabu assessmentofsalivaryglandfunctionusingsalivaryscintigraphyinpreandpostradioactiveiodinetherapyindiagnosedthyroidcarcinomapatients AT shefaliwaghray assessmentofsalivaryglandfunctionusingsalivaryscintigraphyinpreandpostradioactiveiodinetherapyindiagnosedthyroidcarcinomapatients AT rahulmarshal assessmentofsalivaryglandfunctionusingsalivaryscintigraphyinpreandpostradioactiveiodinetherapyindiagnosedthyroidcarcinomapatients AT sharathchandrabontha assessmentofsalivaryglandfunctionusingsalivaryscintigraphyinpreandpostradioactiveiodinetherapyindiagnosedthyroidcarcinomapatients AT reddylavanya assessmentofsalivaryglandfunctionusingsalivaryscintigraphyinpreandpostradioactiveiodinetherapyindiagnosedthyroidcarcinomapatients AT sudheerkanth assessmentofsalivaryglandfunctionusingsalivaryscintigraphyinpreandpostradioactiveiodinetherapyindiagnosedthyroidcarcinomapatients |
_version_ |
1724479662175813632 |