Determination of Lekethromycin, a Novel Macrolide Lactone, in Rat Plasma by UPLC-MS/MS and Its Application to a Pharmacokinetic Study

Determination of Lekethromycin, a Novel Macrolide Lactone, in Rat Plasma by UPLC-MS/MS and Its Application to a Pharmacokinetic Study

Lekethromycin, a new macrolide lactone, exhibits significant antibacterial activity. In this study, a reliable analytical ultrahigh-performance liquid chromatography electrospray ionization quadrupole Orbitrap high-resolution mass spectrometry (UPLC-ESI-Orbitrap-MS) method was established and valida...

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Bibliographic Details
Main Authors: Hongzhi Xiao, Pan Sun, Jicheng Qiu, Jianzhong Wang, Lei Yan, Suxia Zhang, Xingyuan Cao
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
UPLC-ESI-Orbitrap-MS
lekethromycin
rats
pharmacokinetic
Online Access:https://www.mdpi.com/1420-3049/25/20/4676

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