Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits

Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits

Isolated populations can provide useful information on low-frequency variants for dissecting genetic architecture of complex traits. Here, Zeggini and colleagues show enrichment of rare and low-frequency variants and 8 novel low-frequency variant signals for cardiometabolic traits in two Greek isola...

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Main Authors: Lorraine Southam, Arthur Gilly, Dániel Süveges, Aliki-Eleni Farmaki, Jeremy Schwartzentruber, Ioanna Tachmazidou, Angela Matchan, Nigel W. Rayner, Emmanouil Tsafantakis, Maria Karaleftheri, Yali Xue, George Dedoussis, Eleftheria Zeggini
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15606
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spelling doaj-e3b1f1065eac445cb9cf66847168b0572021-05-11T07:03:58ZengNature Publishing GroupNature Communications2041-17232017-05-018111110.1038/ncomms15606Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traitsLorraine Southam0Arthur Gilly1Dániel Süveges2Aliki-Eleni Farmaki3Jeremy Schwartzentruber4Ioanna Tachmazidou5Angela Matchan6Nigel W. Rayner7Emmanouil Tsafantakis8Maria Karaleftheri9Yali Xue10George Dedoussis11Eleftheria Zeggini12Wellcome Trust Sanger InstituteWellcome Trust Sanger InstituteWellcome Trust Sanger InstituteDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio UniversityWellcome Trust Sanger InstituteWellcome Trust Sanger InstituteWellcome Trust Sanger InstituteWellcome Trust Sanger InstituteAnogia Medical CentreEchinos Medical Centre, EchinosWellcome Trust Sanger InstituteDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio UniversityWellcome Trust Sanger InstituteIsolated populations can provide useful information on low-frequency variants for dissecting genetic architecture of complex traits. Here, Zeggini and colleagues show enrichment of rare and low-frequency variants and 8 novel low-frequency variant signals for cardiometabolic traits in two Greek isolated populationshttps://doi.org/10.1038/ncomms15606
collection DOAJ
language English
format Article
sources DOAJ
author Lorraine Southam
Arthur Gilly
Dániel Süveges
Aliki-Eleni Farmaki
Jeremy Schwartzentruber
Ioanna Tachmazidou
Angela Matchan
Nigel W. Rayner
Emmanouil Tsafantakis
Maria Karaleftheri
Yali Xue
George Dedoussis
Eleftheria Zeggini
spellingShingle Lorraine Southam
Arthur Gilly
Dániel Süveges
Aliki-Eleni Farmaki
Jeremy Schwartzentruber
Ioanna Tachmazidou
Angela Matchan
Nigel W. Rayner
Emmanouil Tsafantakis
Maria Karaleftheri
Yali Xue
George Dedoussis
Eleftheria Zeggini
Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
Nature Communications
author_facet Lorraine Southam
Arthur Gilly
Dániel Süveges
Aliki-Eleni Farmaki
Jeremy Schwartzentruber
Ioanna Tachmazidou
Angela Matchan
Nigel W. Rayner
Emmanouil Tsafantakis
Maria Karaleftheri
Yali Xue
George Dedoussis
Eleftheria Zeggini
author_sort Lorraine Southam
title Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
title_short Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
title_full Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
title_fullStr Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
title_full_unstemmed Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
title_sort whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description Isolated populations can provide useful information on low-frequency variants for dissecting genetic architecture of complex traits. Here, Zeggini and colleagues show enrichment of rare and low-frequency variants and 8 novel low-frequency variant signals for cardiometabolic traits in two Greek isolated populations
url https://doi.org/10.1038/ncomms15606
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