The effect of octopamine on the locust stomatogastric nervous system

Octopamine (OA) is a prominent neuromodulator of invertebrate nervous systems, 33 influencing multiple physiological processes. Among its many roles in insects are the 34 initiation and maintenance of various rhythmic behaviors. Here, the neuromodulatory 35 effects of OA on the components of the loc...

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Main Authors: David eRand, Daniel eKnebel, Amir eAyali
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00288/full
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spelling doaj-e3b68fb5995d4f44917551b4052b98702020-11-24T20:59:16ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2012-07-01310.3389/fphys.2012.0028829247The effect of octopamine on the locust stomatogastric nervous systemDavid eRand0Daniel eKnebel1Daniel eKnebel2Amir eAyali3Amir eAyali4Tel Aviv UniversityTel Aviv UniversityTel Aviv UniversityTel Aviv UniversityTel Aviv UniversityOctopamine (OA) is a prominent neuromodulator of invertebrate nervous systems, 33 influencing multiple physiological processes. Among its many roles in insects are the 34 initiation and maintenance of various rhythmic behaviors. Here, the neuromodulatory 35 effects of OA on the components of the locust stomatogastric nervous system (STNS) 36 were studied, and one putative source of OA modulation of the system was identified. 37 Bath application of OA was found to abolish the endogenous rhythmic output of the 38 fully isolated frontal ganglion (FG), while stimulating motor activity of the fully 39 isolated hypocerebral ganglion (HG). OA also induced rhythmic movements in a 40 foregut preparation with intact HG innervation. Complex dose-dependent effects of 41 OA on interconnected FG-HG preparations were seen: 10-5M OA accelerated the 42 rhythmic activity of both the HG and FG in a synchronized manner, while 10-4M OA 43 decreased both rhythms. Intracellular stimulation of an identified octopaminergic 44 dorsal unpaired median (DUM) neuron in the subesophageal ganglion (SEG) was 45 found to exert a similar effect on the FG motor output as that of OA application. Our 46 findings suggest a mechanism of regulation of insect gut patterns and feeding-related 47 behavior during stress and times of high energy demand.http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00288/fullOctopaminecentral pattern generatorsDUM neuronsLocuststomatogastric nervous system
collection DOAJ
language English
format Article
sources DOAJ
author David eRand
Daniel eKnebel
Daniel eKnebel
Amir eAyali
Amir eAyali
spellingShingle David eRand
Daniel eKnebel
Daniel eKnebel
Amir eAyali
Amir eAyali
The effect of octopamine on the locust stomatogastric nervous system
Frontiers in Physiology
Octopamine
central pattern generators
DUM neurons
Locust
stomatogastric nervous system
author_facet David eRand
Daniel eKnebel
Daniel eKnebel
Amir eAyali
Amir eAyali
author_sort David eRand
title The effect of octopamine on the locust stomatogastric nervous system
title_short The effect of octopamine on the locust stomatogastric nervous system
title_full The effect of octopamine on the locust stomatogastric nervous system
title_fullStr The effect of octopamine on the locust stomatogastric nervous system
title_full_unstemmed The effect of octopamine on the locust stomatogastric nervous system
title_sort effect of octopamine on the locust stomatogastric nervous system
publisher Frontiers Media S.A.
series Frontiers in Physiology
issn 1664-042X
publishDate 2012-07-01
description Octopamine (OA) is a prominent neuromodulator of invertebrate nervous systems, 33 influencing multiple physiological processes. Among its many roles in insects are the 34 initiation and maintenance of various rhythmic behaviors. Here, the neuromodulatory 35 effects of OA on the components of the locust stomatogastric nervous system (STNS) 36 were studied, and one putative source of OA modulation of the system was identified. 37 Bath application of OA was found to abolish the endogenous rhythmic output of the 38 fully isolated frontal ganglion (FG), while stimulating motor activity of the fully 39 isolated hypocerebral ganglion (HG). OA also induced rhythmic movements in a 40 foregut preparation with intact HG innervation. Complex dose-dependent effects of 41 OA on interconnected FG-HG preparations were seen: 10-5M OA accelerated the 42 rhythmic activity of both the HG and FG in a synchronized manner, while 10-4M OA 43 decreased both rhythms. Intracellular stimulation of an identified octopaminergic 44 dorsal unpaired median (DUM) neuron in the subesophageal ganglion (SEG) was 45 found to exert a similar effect on the FG motor output as that of OA application. Our 46 findings suggest a mechanism of regulation of insect gut patterns and feeding-related 47 behavior during stress and times of high energy demand.
topic Octopamine
central pattern generators
DUM neurons
Locust
stomatogastric nervous system
url http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00288/full
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