Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study
Abstract Background 25(OH) vitamin D levels are inversely associated with respiratory infections and childhood wheezing. Objective To evaluate serum 25(OH) vitamin D levels in infants and toddlers with acute bronchiolitis, compared to subjects with non-respiratory febrile illness. Methods A prospect...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-04-01
|
Series: | BMC Pediatrics |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12887-021-02666-4 |
id |
doaj-e3b6a17915a647539f1e36e9f4556d52 |
---|---|
record_format |
Article |
spelling |
doaj-e3b6a17915a647539f1e36e9f4556d522021-05-02T11:15:48ZengBMCBMC Pediatrics1471-24312021-04-012111810.1186/s12887-021-02666-4Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control studyInbal Golan-Tripto0Neta Loewenthal1Asher Tal2Yotam Dizitzer3Yael Baumfeld4Aviv Goldbart5Department of Pediatrics, Soroka University Medical CenterDepartment of Pediatrics, Soroka University Medical CenterFaculty of Health Sciences, Ben-Gurion University of the NegevClinical Research Center, Soroka University Medical CenterFaculty of Health Sciences, Ben-Gurion University of the NegevDepartment of Pediatrics, Soroka University Medical CenterAbstract Background 25(OH) vitamin D levels are inversely associated with respiratory infections and childhood wheezing. Objective To evaluate serum 25(OH) vitamin D levels in infants and toddlers with acute bronchiolitis, compared to subjects with non-respiratory febrile illness. Methods A prospective cross-sectional case-control study which compared serum 25(OH) vitamin D levels between infants and toddlers diagnosed with acute bronchiolitis to subjects with non-respiratory febrile illness. Multivariate logistic regression, adjusted for age, sex, ethnicity and nutrition was performed. Correlation between serum vitamin D levels and bronchiolitis severity was assessed via Modified Tal Score and length of hospital stay (LOS). Results One hundred twenty-seven patients aged < 24 months were recruited; 80 diagnosed with acute bronchiolitis and 47 patients with non- respiratory febrile illnesses. Both groups had similar demographics aside from age (median [IQR] 5 [3–9] vs. 9 [5–16] months in the bronchiolitis group compared to control group (p = 0.002)). Serum 25(OH) vitamin D levels were significantly lower in the bronchiolitis group; median [IQR] 28[18–52] vs. 50[25–79] nmol/L, respectively, (p = 0.005). Deficient vitamin D levels (< 50 nmol/L) was found more frequently in the bronchiolitis group than controls; 73% vs. 51% (p = 0.028). Multivariate logistic regression showed vitamin D deficiency was more probable in bronchiolitis patients; OR [95% CI] 3.139[1.369–7.195]. No correlation was found between serum vitamin D levels and bronchiolitis severity, which was assessed via Modified Tal Score and by length of hospital stay. Conclusion Children with acute bronchiolitis displayed significantly lower vitamin D levels than children with non-respiratory acute febrile illnesses.https://doi.org/10.1186/s12887-021-02666-4BronchiolitisVitamin D deficiencyVitamin D statusChildren |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Inbal Golan-Tripto Neta Loewenthal Asher Tal Yotam Dizitzer Yael Baumfeld Aviv Goldbart |
spellingShingle |
Inbal Golan-Tripto Neta Loewenthal Asher Tal Yotam Dizitzer Yael Baumfeld Aviv Goldbart Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study BMC Pediatrics Bronchiolitis Vitamin D deficiency Vitamin D status Children |
author_facet |
Inbal Golan-Tripto Neta Loewenthal Asher Tal Yotam Dizitzer Yael Baumfeld Aviv Goldbart |
author_sort |
Inbal Golan-Tripto |
title |
Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study |
title_short |
Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study |
title_full |
Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study |
title_fullStr |
Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study |
title_full_unstemmed |
Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study |
title_sort |
vitamin d deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study |
publisher |
BMC |
series |
BMC Pediatrics |
issn |
1471-2431 |
publishDate |
2021-04-01 |
description |
Abstract Background 25(OH) vitamin D levels are inversely associated with respiratory infections and childhood wheezing. Objective To evaluate serum 25(OH) vitamin D levels in infants and toddlers with acute bronchiolitis, compared to subjects with non-respiratory febrile illness. Methods A prospective cross-sectional case-control study which compared serum 25(OH) vitamin D levels between infants and toddlers diagnosed with acute bronchiolitis to subjects with non-respiratory febrile illness. Multivariate logistic regression, adjusted for age, sex, ethnicity and nutrition was performed. Correlation between serum vitamin D levels and bronchiolitis severity was assessed via Modified Tal Score and length of hospital stay (LOS). Results One hundred twenty-seven patients aged < 24 months were recruited; 80 diagnosed with acute bronchiolitis and 47 patients with non- respiratory febrile illnesses. Both groups had similar demographics aside from age (median [IQR] 5 [3–9] vs. 9 [5–16] months in the bronchiolitis group compared to control group (p = 0.002)). Serum 25(OH) vitamin D levels were significantly lower in the bronchiolitis group; median [IQR] 28[18–52] vs. 50[25–79] nmol/L, respectively, (p = 0.005). Deficient vitamin D levels (< 50 nmol/L) was found more frequently in the bronchiolitis group than controls; 73% vs. 51% (p = 0.028). Multivariate logistic regression showed vitamin D deficiency was more probable in bronchiolitis patients; OR [95% CI] 3.139[1.369–7.195]. No correlation was found between serum vitamin D levels and bronchiolitis severity, which was assessed via Modified Tal Score and by length of hospital stay. Conclusion Children with acute bronchiolitis displayed significantly lower vitamin D levels than children with non-respiratory acute febrile illnesses. |
topic |
Bronchiolitis Vitamin D deficiency Vitamin D status Children |
url |
https://doi.org/10.1186/s12887-021-02666-4 |
work_keys_str_mv |
AT inbalgolantripto vitaminddeficiencyinchildrenwithacutebronchiolitisaprospectivecrosssectionalcasecontrolstudy AT netaloewenthal vitaminddeficiencyinchildrenwithacutebronchiolitisaprospectivecrosssectionalcasecontrolstudy AT ashertal vitaminddeficiencyinchildrenwithacutebronchiolitisaprospectivecrosssectionalcasecontrolstudy AT yotamdizitzer vitaminddeficiencyinchildrenwithacutebronchiolitisaprospectivecrosssectionalcasecontrolstudy AT yaelbaumfeld vitaminddeficiencyinchildrenwithacutebronchiolitisaprospectivecrosssectionalcasecontrolstudy AT avivgoldbart vitaminddeficiencyinchildrenwithacutebronchiolitisaprospectivecrosssectionalcasecontrolstudy |
_version_ |
1721492481268252672 |