The study of structural-mechanical properties of diltiazem suppositories

• Main Authors: L. К. Kuchina, S. А. Gladyshevа, I. A. Puchalskaya
• Format: Article
• Language: English
• Published: Zaporozhye State Medical University 2015-08-01
• Series: Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
• Subjects: Diltiazem; Suppositories; Transition Temperature; Rheology; «Mechanical Phenomena»
• Online Access: http://pharmed.zsmu.edu.ua/article/view/45197/43754

Using alternative ways of diltiazem absorption, in particular, rectal, will allow to improve its bioavailability and efficiency. Aim. To study the structural-mechanical properties of diltiazem suppositories. Methods and results. For the investigation of the influence of temperature of suppository manufacturing technological process on the structural-mechanical properties of diltiazem rectal dosage rheological properties of the suppository mass with diltiazem on the factory fat base with 2% of distilled monoglycerides has been studied. Conclusion. It has been determined that temperature 50-55ºС for the technological operations of homogenization and pouring suppositories is optimal and necessary fluidity of the suppository mass with even distribution of active substances and excipients is provided.