The Risk of Recrystallization: Changes to the Toxicity and Morphology of Pyrimethamine
PURPOSE. Pyrimethamine, an anti-malarial agent known to exhibit solid state polymorphism, may be purified by means of recrystallization. Recrystallization may alter the solid state chemistry of pharmaceuticals, which may impact the toxicity and/or manufacturability thereof. We evaluated the risks a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Canadian Society for Pharmaceutical Sciences
2014-04-01
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| Series: | Journal of Pharmacy & Pharmaceutical Sciences |
| Online Access: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/18912 |