Estrogen receptors genotypes and canine mammary neoplasia
Abstract Background Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked individual genetic variability concerning estrogens biosynthesis, metabol...
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doaj-e3e7b7cd3c864a74be7210516c78d4002020-11-25T03:12:44ZengBMCBMC Veterinary Research1746-61482019-09-0115111010.1186/s12917-019-2062-yEstrogen receptors genotypes and canine mammary neoplasiaAna Canadas-Sousa0Marta Santos1Bárbara Leal2Rui Medeiros3Patrícia Dias-Pereira4Department of Pathology and Molecular Immunology, Instituto Ciências Biomédicas Abel Salazar, ICBAS – UPorto, University of PortoDepartment of Microscopy, Instituto Ciências Biomédicas Abel Salazar, ICBAS – UPorto, University of PortoDepartment of Pathology and Molecular Immunology, Instituto Ciências Biomédicas Abel Salazar, ICBAS – UPorto, University of PortoMolecular Oncology and Viral Pathology Group, IPO-Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto)Department of Pathology and Molecular Immunology, Instituto Ciências Biomédicas Abel Salazar, ICBAS – UPorto, University of PortoAbstract Background Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked individual genetic variability concerning estrogens biosynthesis, metabolism and mechanism of action was recognized and associated with human breast cancer susceptibility, clinical features and progression. Although some genetic variations in canine ESR1 gene were reported, their influence in clinicopathological features and progression of canine mammary tumors has not been fully evaluated. This study aims to assess the influence of SNPs in ESR1 gene (rs397512133, rs397510462, rs851327560, rs397510612, rs852887655, rs852684753 and rs852398698) in canine mammary tumors characteristics and progression. A group of 155 non-neutered bitches with mammary tumors was included in the study. Follow-up information was assessed 24 months after surgery. Results Genetic profiles associated with a later onset of mammary tumors and less aggressive clinicopathological features, namely smaller tumor size (≤ 3 cm) with extensive tubular differentiation and low canine-adapted prognostic index (vet-NPI), were identified in this study. Conclusions Our data suggest that the ESR1 genetic profile may help on the decision regarding the selection of individual tailored preventive measures against canine mammary tumors development, such as early neutering.http://link.springer.com/article/10.1186/s12917-019-2062-yCanine mammary tumorsESR1 geneSNPGenetic profile |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Canadas-Sousa Marta Santos Bárbara Leal Rui Medeiros Patrícia Dias-Pereira |
spellingShingle |
Ana Canadas-Sousa Marta Santos Bárbara Leal Rui Medeiros Patrícia Dias-Pereira Estrogen receptors genotypes and canine mammary neoplasia BMC Veterinary Research Canine mammary tumors ESR1 gene SNP Genetic profile |
author_facet |
Ana Canadas-Sousa Marta Santos Bárbara Leal Rui Medeiros Patrícia Dias-Pereira |
author_sort |
Ana Canadas-Sousa |
title |
Estrogen receptors genotypes and canine mammary neoplasia |
title_short |
Estrogen receptors genotypes and canine mammary neoplasia |
title_full |
Estrogen receptors genotypes and canine mammary neoplasia |
title_fullStr |
Estrogen receptors genotypes and canine mammary neoplasia |
title_full_unstemmed |
Estrogen receptors genotypes and canine mammary neoplasia |
title_sort |
estrogen receptors genotypes and canine mammary neoplasia |
publisher |
BMC |
series |
BMC Veterinary Research |
issn |
1746-6148 |
publishDate |
2019-09-01 |
description |
Abstract Background Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked individual genetic variability concerning estrogens biosynthesis, metabolism and mechanism of action was recognized and associated with human breast cancer susceptibility, clinical features and progression. Although some genetic variations in canine ESR1 gene were reported, their influence in clinicopathological features and progression of canine mammary tumors has not been fully evaluated. This study aims to assess the influence of SNPs in ESR1 gene (rs397512133, rs397510462, rs851327560, rs397510612, rs852887655, rs852684753 and rs852398698) in canine mammary tumors characteristics and progression. A group of 155 non-neutered bitches with mammary tumors was included in the study. Follow-up information was assessed 24 months after surgery. Results Genetic profiles associated with a later onset of mammary tumors and less aggressive clinicopathological features, namely smaller tumor size (≤ 3 cm) with extensive tubular differentiation and low canine-adapted prognostic index (vet-NPI), were identified in this study. Conclusions Our data suggest that the ESR1 genetic profile may help on the decision regarding the selection of individual tailored preventive measures against canine mammary tumors development, such as early neutering. |
topic |
Canine mammary tumors ESR1 gene SNP Genetic profile |
url |
http://link.springer.com/article/10.1186/s12917-019-2062-y |
work_keys_str_mv |
AT anacanadassousa estrogenreceptorsgenotypesandcaninemammaryneoplasia AT martasantos estrogenreceptorsgenotypesandcaninemammaryneoplasia AT barbaraleal estrogenreceptorsgenotypesandcaninemammaryneoplasia AT ruimedeiros estrogenreceptorsgenotypesandcaninemammaryneoplasia AT patriciadiaspereira estrogenreceptorsgenotypesandcaninemammaryneoplasia |
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