Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis
Brain morphogenesis is an important process contributing to higher-order cognition, however our knowledge about its biological basis is largely incomplete. Here, authors analyzed 118 neuroanatomical parameters in 1,566 mutant mouse lines to identify 198 genes whose disruptions yield neuroanatomical...
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| Language: | English |
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Nature Publishing Group
2019-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11431-2 |
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doaj-e3ec51735a66472fbde33afd3c90e6262021-05-11T12:02:51ZengNature Publishing GroupNature Communications2041-17232019-08-0110111210.1038/s41467-019-11431-2Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesisStephan C. Collins0Anna Mikhaleva1Katarina Vrcelj2Valerie E. Vancollie3Christel Wagner4Nestor Demeure5Helen Whitley6Meghna Kannan7Rebecca Balz8Lauren F. E. Anthony9Andrew Edwards10Hervé Moine11Jacqueline K. White12David J. Adams13Alexandre Reymond14Christopher J. Lelliott15Caleb Webber16Binnaz Yalcin17Institut de Génétique et de Biologie Moléculaire et CellulaireCenter for Integrative Genomics, University of LausanneDepartment of Physiology, Anatomy and Genetics, University of OxfordWellcome Sanger InstituteInstitut de Génétique et de Biologie Moléculaire et CellulaireInstitut de Génétique et de Biologie Moléculaire et CellulaireInstitut de Génétique et de Biologie Moléculaire et CellulaireInstitut de Génétique et de Biologie Moléculaire et CellulaireCenter for Integrative Genomics, University of LausanneWellcome Sanger InstituteWoodland View Hospital, NHS Ayrshire and ArranInstitut de Génétique et de Biologie Moléculaire et CellulaireWellcome Sanger InstituteWellcome Sanger InstituteCenter for Integrative Genomics, University of LausanneWellcome Sanger InstituteDepartment of Physiology, Anatomy and Genetics, University of OxfordInstitut de Génétique et de Biologie Moléculaire et CellulaireBrain morphogenesis is an important process contributing to higher-order cognition, however our knowledge about its biological basis is largely incomplete. Here, authors analyzed 118 neuroanatomical parameters in 1,566 mutant mouse lines to identify 198 genes whose disruptions yield neuroanatomical phenotypeshttps://doi.org/10.1038/s41467-019-11431-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Stephan C. Collins Anna Mikhaleva Katarina Vrcelj Valerie E. Vancollie Christel Wagner Nestor Demeure Helen Whitley Meghna Kannan Rebecca Balz Lauren F. E. Anthony Andrew Edwards Hervé Moine Jacqueline K. White David J. Adams Alexandre Reymond Christopher J. Lelliott Caleb Webber Binnaz Yalcin |
| spellingShingle |
Stephan C. Collins Anna Mikhaleva Katarina Vrcelj Valerie E. Vancollie Christel Wagner Nestor Demeure Helen Whitley Meghna Kannan Rebecca Balz Lauren F. E. Anthony Andrew Edwards Hervé Moine Jacqueline K. White David J. Adams Alexandre Reymond Christopher J. Lelliott Caleb Webber Binnaz Yalcin Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis Nature Communications |
| author_facet |
Stephan C. Collins Anna Mikhaleva Katarina Vrcelj Valerie E. Vancollie Christel Wagner Nestor Demeure Helen Whitley Meghna Kannan Rebecca Balz Lauren F. E. Anthony Andrew Edwards Hervé Moine Jacqueline K. White David J. Adams Alexandre Reymond Christopher J. Lelliott Caleb Webber Binnaz Yalcin |
| author_sort |
Stephan C. Collins |
| title |
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis |
| title_short |
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis |
| title_full |
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis |
| title_fullStr |
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis |
| title_full_unstemmed |
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis |
| title_sort |
large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-08-01 |
| description |
Brain morphogenesis is an important process contributing to higher-order cognition, however our knowledge about its biological basis is largely incomplete. Here, authors analyzed 118 neuroanatomical parameters in 1,566 mutant mouse lines to identify 198 genes whose disruptions yield neuroanatomical phenotypes |
| url |
https://doi.org/10.1038/s41467-019-11431-2 |
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