Anti-proliferative activity of ethyl acetate extracts of Tamarix gallica L. grown at different climatic conditions in Algeria

Anti-proliferative activity of ethyl acetate extracts of Tamarix gallica L. grown at different climatic conditions in Algeria

The aerial parts of T. gallica collected from three different locations (arid, humid and semi-arid) were extracted using ethyl acetate. The crude extracts were subjected to phenolic appraisal and antiproliferative activity using ELISA and xCELLigence assays. The total phenolic and flavonoids were ev...

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Main Authors: Fellah Ouroud, Hameurlaine Samir, Gherraf Noureddine, Zellagui Amar, Ali Tahar, Abidi Abdennabi, Altun Muhammed, Demirtas Ibrahim, SahinYaglioglu Ayse
Format: Article
Language:English
Published: Sciendo 2018-12-01
Series:Acta Scientifica Naturalis
Subjects:
tamarix gallica
geographic origins
ethyl acetate
phenolic
flavonoids
anti-cancer activity
Online Access:https://doi.org/10.2478/asn-2018-0017
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spelling doaj-e3f1aba4243b4989a8ec7c24fdc45e362021-09-06T19:41:19ZengSciendoActa Scientifica Naturalis2367-51442018-12-0152233110.2478/asn-2018-0017asn-2018-0017Anti-proliferative activity of ethyl acetate extracts of Tamarix gallica L. grown at different climatic conditions in AlgeriaFellah Ouroud0Hameurlaine Samir1Gherraf Noureddine2Zellagui Amar3Ali Tahar4Abidi Abdennabi5Altun Muhammed6Demirtas Ibrahim7SahinYaglioglu Ayse8Faculty of sciences, department of natural and life sciences, university of Badji Mokhtar Annaba, 23000, AlgeriaLaboratory of Natural Resources and Management of Sensitive Environments, Larbi ben M’hidiniversity, Oum El Bouaghi, AlgeriaLaboratory of Natural Resources and Management of Sensitive Environments, Larbi ben M’hidiniversity, Oum El Bouaghi, AlgeriaLaboratory of Biomolecules and Plant Breeding, Life Science and Nature Department, Faculty of Exact Science and Life Science and Nature, University of Larbi Ben MhidiOum El Bouaghi, Algeria.Faculty of sciences, department of natural and life sciences, university of Badji Mokhtar Annaba, 23000, AlgeriaDepartment of Process Engineering, Badji Mokhtar University, Annaba23000, AlgeriaLaboratory of Plant Research, Department of Chemistry, Faculty of Science, Uluyazi Campus, CankiriKaratekin University, Cankiri, Department of ChemistryTurkeyLaboratory of Plant Research, Department of Chemistry, Faculty of Science, Uluyazi Campus, CankiriKaratekin University, Cankiri, Department of ChemistryTurkeyLaboratory of Plant Research, Department of Chemistry, Faculty of Science, Uluyazi Campus, CankiriKaratekin University, Cankiri, Department of ChemistryTurkeyThe aerial parts of T. gallica collected from three different locations (arid, humid and semi-arid) were extracted using ethyl acetate. The crude extracts were subjected to phenolic appraisal and antiproliferative activity using ELISA and xCELLigence assays. The total phenolic and flavonoids were evaluated using appropriate techniques to give a yield of total phenolics ranging between 238.46 and 348.56 mg GAE (Gallic acid equivalent)/g dry weight extract. The flavonoids yield was found to vary from 36.6 to 103.14 mg QE (quercetin equivalent)/g dry weight extract. Moreover, the extracts were tested against rat brain tumor (C6) and human cervix carcinoma (HeLa) cell lines and displayed important differences in activity. These disparities highlighted the effect of climatic factors as quality determinants of secondary metabolites and therefore as a key control of the biological therapeutic effect.https://doi.org/10.2478/asn-2018-0017tamarix gallicageographic originsethyl acetatephenolicflavonoidsanti-cancer activity
collection DOAJ
language English
format Article
sources DOAJ
author Fellah Ouroud
Hameurlaine Samir
Gherraf Noureddine
Zellagui Amar
Ali Tahar
Abidi Abdennabi
Altun Muhammed
Demirtas Ibrahim
SahinYaglioglu Ayse
spellingShingle Fellah Ouroud
Hameurlaine Samir
Gherraf Noureddine
Zellagui Amar
Ali Tahar
Abidi Abdennabi
Altun Muhammed
Demirtas Ibrahim
SahinYaglioglu Ayse
Anti-proliferative activity of ethyl acetate extracts of Tamarix gallica L. grown at different climatic conditions in Algeria
Acta Scientifica Naturalis
tamarix gallica
geographic origins
ethyl acetate
phenolic
flavonoids
anti-cancer activity
author_facet Fellah Ouroud
Hameurlaine Samir
Gherraf Noureddine
Zellagui Amar
Ali Tahar
Abidi Abdennabi
Altun Muhammed
Demirtas Ibrahim
SahinYaglioglu Ayse
author_sort Fellah Ouroud
title Anti-proliferative activity of ethyl acetate extracts of Tamarix gallica L. grown at different climatic conditions in Algeria
title_short Anti-proliferative activity of ethyl acetate extracts of Tamarix gallica L. grown at different climatic conditions in Algeria
title_full Anti-proliferative activity of ethyl acetate extracts of Tamarix gallica L. grown at different climatic conditions in Algeria
title_fullStr Anti-proliferative activity of ethyl acetate extracts of Tamarix gallica L. grown at different climatic conditions in Algeria
title_full_unstemmed Anti-proliferative activity of ethyl acetate extracts of Tamarix gallica L. grown at different climatic conditions in Algeria
title_sort anti-proliferative activity of ethyl acetate extracts of tamarix gallica l. grown at different climatic conditions in algeria
publisher Sciendo
series Acta Scientifica Naturalis
issn 2367-5144
publishDate 2018-12-01
description The aerial parts of T. gallica collected from three different locations (arid, humid and semi-arid) were extracted using ethyl acetate. The crude extracts were subjected to phenolic appraisal and antiproliferative activity using ELISA and xCELLigence assays. The total phenolic and flavonoids were evaluated using appropriate techniques to give a yield of total phenolics ranging between 238.46 and 348.56 mg GAE (Gallic acid equivalent)/g dry weight extract. The flavonoids yield was found to vary from 36.6 to 103.14 mg QE (quercetin equivalent)/g dry weight extract. Moreover, the extracts were tested against rat brain tumor (C6) and human cervix carcinoma (HeLa) cell lines and displayed important differences in activity. These disparities highlighted the effect of climatic factors as quality determinants of secondary metabolites and therefore as a key control of the biological therapeutic effect.
topic tamarix gallica
geographic origins
ethyl acetate
phenolic
flavonoids
anti-cancer activity
url https://doi.org/10.2478/asn-2018-0017
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AT gherrafnoureddine antiproliferativeactivityofethylacetateextractsoftamarixgallicalgrownatdifferentclimaticconditionsinalgeria
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