Тhe Impact Of Positive Acceleration (+Gz) on Antioxidant Capacity and Histopathological Alterations in Different Organs and Tissues in Rats
Since the early 1940s, a significant amount of research has been conducted to describe the impact of the high-G acceleration on the cardiovascular system. The objective of the present study was to examine the role of the antioxidant enzyme system under biodynamic stress in the liver, heart and gastr...
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doaj-e3f2517b83ec4655b0f2ef8cb31a49322021-09-05T14:00:39ZengSciendoSerbian Journal of Experimental and Clinical Research 1820-86652335-075X2017-10-0118320321210.1515/sjecr-2016-0066sjecr-2016-0066Тhe Impact Of Positive Acceleration (+Gz) on Antioxidant Capacity and Histopathological Alterations in Different Organs and Tissues in RatsRistic Jelena0Nikolic Tamara1Jeremic Jovana2Stojic Isidora3Janicijevic-Hudomal Snezana4Popovic Mira5Arsic-Komljenovic Gordana6Radojevic-Popovic Radmila7Srejovic Ivan8Zivkovic Vladimir9Richter Gedeon Representative Office for Serbia, Belgrade, SerbiaDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, SerbiaDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, SerbiaDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, SerbiaDepartment of Pharmacology, Medical Faculty, University of Pristina, Kosovska Mitrovica , SerbiaDepartment of Chemistry, Faculty of Sciences, University of Novi Sad, Novi Sad, SerbiaHigh Medical College of Professional Studies “Milutin Milankovic”, Belgrade, SerbiaSpecial Hospital for Hyperbaric Medicine, Belgrade, SerbiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, SerbiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, SerbiaSince the early 1940s, a significant amount of research has been conducted to describe the impact of the high-G acceleration on the cardiovascular system. The objective of the present study was to examine the role of the antioxidant enzyme system under biodynamic stress in the liver, heart and gastric mucosa in response to high-magnitude +Gz exposure in a rat model. Twenty adult male Wistar albino rats (10 rats per group; 9-11 weeks old, 200-250 g b.w.) were divided into the following two groups: control and G (exposed to a biodynamic stress model under positive (+7 Gz) acceleration for 40 s). The influence of acute biodynamic stress on pro-oxidative parameters in the rat liver (xanthine oxidase (XOD), catalase (CAT), peroxidase (Px), glutathione peroxidase (GSH-Px), total content of glutathione (GSH), lipid peroxidation (LPx)) and on histopathological alterations in the liver, cardiac muscle and gastric mucosa was examined. Biodynamic stress resulting from positive (+7 Gz) acceleration resulted in a highly statistically signifi cant increase of CAT GSH-Px activity compared to the control group. The LPx levels were significantly decreased, but the GSH contents and the activities of other enzymes were not significantly changed. Significant microscopic changes in the liver, heart and gastric mucosa were observed in the G group. These results clearly indicate that +Gz acceleration alters biochemical systems. These alterations in cellular processes may be mediated by influences of hypoxia or ischaemia via changes in the antioxidant capacity.https://doi.org/10.1515/sjecr-2016-0066+gz accelerationantioxidant enzymeliverheartgastric mucosarats |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ristic Jelena Nikolic Tamara Jeremic Jovana Stojic Isidora Janicijevic-Hudomal Snezana Popovic Mira Arsic-Komljenovic Gordana Radojevic-Popovic Radmila Srejovic Ivan Zivkovic Vladimir |
spellingShingle |
Ristic Jelena Nikolic Tamara Jeremic Jovana Stojic Isidora Janicijevic-Hudomal Snezana Popovic Mira Arsic-Komljenovic Gordana Radojevic-Popovic Radmila Srejovic Ivan Zivkovic Vladimir Тhe Impact Of Positive Acceleration (+Gz) on Antioxidant Capacity and Histopathological Alterations in Different Organs and Tissues in Rats Serbian Journal of Experimental and Clinical Research +gz acceleration antioxidant enzyme liver heart gastric mucosa rats |
author_facet |
Ristic Jelena Nikolic Tamara Jeremic Jovana Stojic Isidora Janicijevic-Hudomal Snezana Popovic Mira Arsic-Komljenovic Gordana Radojevic-Popovic Radmila Srejovic Ivan Zivkovic Vladimir |
author_sort |
Ristic Jelena |
title |
Тhe Impact Of Positive Acceleration (+Gz) on Antioxidant Capacity and Histopathological Alterations in Different Organs and Tissues in Rats |
title_short |
Тhe Impact Of Positive Acceleration (+Gz) on Antioxidant Capacity and Histopathological Alterations in Different Organs and Tissues in Rats |
title_full |
Тhe Impact Of Positive Acceleration (+Gz) on Antioxidant Capacity and Histopathological Alterations in Different Organs and Tissues in Rats |
title_fullStr |
Тhe Impact Of Positive Acceleration (+Gz) on Antioxidant Capacity and Histopathological Alterations in Different Organs and Tissues in Rats |
title_full_unstemmed |
Тhe Impact Of Positive Acceleration (+Gz) on Antioxidant Capacity and Histopathological Alterations in Different Organs and Tissues in Rats |
title_sort |
тhe impact of positive acceleration (+gz) on antioxidant capacity and histopathological alterations in different organs and tissues in rats |
publisher |
Sciendo |
series |
Serbian Journal of Experimental and Clinical Research |
issn |
1820-8665 2335-075X |
publishDate |
2017-10-01 |
description |
Since the early 1940s, a significant amount of research has been conducted to describe the impact of the high-G acceleration on the cardiovascular system. The objective of the present study was to examine the role of the antioxidant enzyme system under biodynamic stress in the liver, heart and gastric mucosa in response to high-magnitude +Gz exposure in a rat model. Twenty adult male Wistar albino rats (10 rats per group; 9-11 weeks old, 200-250 g b.w.) were divided into the following two groups: control and G (exposed to a biodynamic stress model under positive (+7 Gz) acceleration for 40 s). The influence of acute biodynamic stress on pro-oxidative parameters in the rat liver (xanthine oxidase (XOD), catalase (CAT), peroxidase (Px), glutathione peroxidase (GSH-Px), total content of glutathione (GSH), lipid peroxidation (LPx)) and on histopathological alterations in the liver, cardiac muscle and gastric mucosa was examined. Biodynamic stress resulting from positive (+7 Gz) acceleration resulted in a highly statistically signifi cant increase of CAT GSH-Px activity compared to the control group. The LPx levels were significantly decreased, but the GSH contents and the activities of other enzymes were not significantly changed. Significant microscopic changes in the liver, heart and gastric mucosa were observed in the G group. These results clearly indicate that +Gz acceleration alters biochemical systems. These alterations in cellular processes may be mediated by influences of hypoxia or ischaemia via changes in the antioxidant capacity. |
topic |
+gz acceleration antioxidant enzyme liver heart gastric mucosa rats |
url |
https://doi.org/10.1515/sjecr-2016-0066 |
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