Associations between prenatal exposure to cadmium and lead with neural tube defect risks are modified by single-nucleotide polymorphisms of fetal MTHFR and SOD2: a case–control study

Associations between prenatal exposure to cadmium and lead with neural tube defect risks are modified by single-nucleotide polymorphisms of fetal MTHFR and SOD2: a case–control study

Abstract Background Prenatal exposure to heavy metals is implicated in the etiology of birth defects. We investigated whether concentrations of cadmium (Cd) and lead (Pb) in umbilical cord tissue are associated with risk for neural tube defects (NTDs) and whether selected genetic variants of the fet...

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Bibliographic Details
Main Authors: Mengyuan Liu, Jinhui Yu, Zaiming Su, Ying Sun, Yaqiong Liu, Qing Xie, Zhiwen Li, Linlin Wang, Jie Zhang, Lei Jin, Aiguo Ren
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Environmental Health
Subjects:
Cadmium
Lead
Neural tube defects
Single-nucleotide polymorphisms
Superoxide dismutase 2 (SOD2)
5,10-methylenetetrahydrofolatereductase (MTHFR)
Online Access:https://doi.org/10.1186/s12940-021-00752-9

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