Quercetin alleviates cadmium chloride-induced renal damage in rats by suppressing endoplasmic reticulum stress through SIRT1-dependent deacetylation of Xbp-1s and eIF2α

Quercetin alleviates cadmium chloride-induced renal damage in rats by suppressing endoplasmic reticulum stress through SIRT1-dependent deacetylation of Xbp-1s and eIF2α

Endoplasmic reticulum (ER) stress plays a key role in cadmium chloride (CdCl2)-induced nephrotoxicity. Sirtuin-1 (SIRT1) is a potent inhibitor of ER stress. In this study, we examined whether the protective effect of quercetin (QUR) against CdCl2-induced nephrotoxicity in rats involved modulation of...

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Bibliographic Details
Main Authors: Ghedeir M. Alshammari, Wahidah H. Al-Qahtani, Nora A. AlFaris, Norah A. Albekairi, Sultan Alqahtani, Refaat Eid, Abu ElGasim A. Yagoub, Laila Naif Al-Harbi, Mohammed Abdo Yahya
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Quercetin
CdCl2
Kidney
SIRT1
Oxidative stress
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221006442

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