A giant mystery in giant cell myocarditis: navigating diagnosis, immunosuppression, and mechanical circulatory support

Abstract Giant cell myocarditis is a rare but often devastating diagnosis. Advances in cardiac imaging and mechanical circulatory support have led to earlier and more frequent diagnoses and successful management. This disease state has wide variation in acuity of presentation, and consequently, opti...

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Main Authors:	Julianne M. Fallon, Alex M. Parker, Steven P. Dunn, Jamie L.W. Kennedy
Format:	Article
Language:	English
Published:	Wiley 2020-02-01
Series:	ESC Heart Failure
Subjects:	Giant cell myocarditis mechanical circulatory support immunosuppression
Online Access:	https://doi.org/10.1002/ehf2.12564

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record_format	Article
spelling	doaj-e40635ee84bf4bfb8d555a67b97ac1af2020-11-25T03:50:59ZengWileyESC Heart Failure2055-58222020-02-017131632010.1002/ehf2.12564A giant mystery in giant cell myocarditis: navigating diagnosis, immunosuppression, and mechanical circulatory supportJulianne M. Fallon0Alex M. Parker1Steven P. Dunn2Jamie L.W. Kennedy3Department of Pharmacy Cleveland Clinic Cleveland OHDivision of Cardiology University of Florida Health Gainesville FL USADepartment of Pharmacy University of Virginia Health System Charlottesville VA USADivision of Cardiology University of California San Francisco San Francisco CA USAAbstract Giant cell myocarditis is a rare but often devastating diagnosis. Advances in cardiac imaging and mechanical circulatory support have led to earlier and more frequent diagnoses and successful management. This disease state has wide variation in acuity of presentation, and consequently, optimal treatment ranging from intensity and type of immunosuppression to mechanical circulatory support is not well defined. The following case describes the management of a patient with an unusual presentation of giant cell myocarditis over a 10 year course of advanced heart failure therapies and immunomodulatory support. This case highlights emerging concepts in the management of giant cell myocarditis including sub‐acute presentations, challenges in diagnosis, and treatment modalities in the modern era.https://doi.org/10.1002/ehf2.12564Giant cell myocarditismechanical circulatory supportimmunosuppression
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Julianne M. Fallon Alex M. Parker Steven P. Dunn Jamie L.W. Kennedy
spellingShingle	Julianne M. Fallon Alex M. Parker Steven P. Dunn Jamie L.W. Kennedy A giant mystery in giant cell myocarditis: navigating diagnosis, immunosuppression, and mechanical circulatory support ESC Heart Failure Giant cell myocarditis mechanical circulatory support immunosuppression
author_facet	Julianne M. Fallon Alex M. Parker Steven P. Dunn Jamie L.W. Kennedy
author_sort	Julianne M. Fallon
title	A giant mystery in giant cell myocarditis: navigating diagnosis, immunosuppression, and mechanical circulatory support
title_short	A giant mystery in giant cell myocarditis: navigating diagnosis, immunosuppression, and mechanical circulatory support
title_full	A giant mystery in giant cell myocarditis: navigating diagnosis, immunosuppression, and mechanical circulatory support
title_fullStr	A giant mystery in giant cell myocarditis: navigating diagnosis, immunosuppression, and mechanical circulatory support
title_full_unstemmed	A giant mystery in giant cell myocarditis: navigating diagnosis, immunosuppression, and mechanical circulatory support
title_sort	giant mystery in giant cell myocarditis: navigating diagnosis, immunosuppression, and mechanical circulatory support
publisher	Wiley
series	ESC Heart Failure
issn	2055-5822
publishDate	2020-02-01
description	Abstract Giant cell myocarditis is a rare but often devastating diagnosis. Advances in cardiac imaging and mechanical circulatory support have led to earlier and more frequent diagnoses and successful management. This disease state has wide variation in acuity of presentation, and consequently, optimal treatment ranging from intensity and type of immunosuppression to mechanical circulatory support is not well defined. The following case describes the management of a patient with an unusual presentation of giant cell myocarditis over a 10 year course of advanced heart failure therapies and immunomodulatory support. This case highlights emerging concepts in the management of giant cell myocarditis including sub‐acute presentations, challenges in diagnosis, and treatment modalities in the modern era.
topic	Giant cell myocarditis mechanical circulatory support immunosuppression
url	https://doi.org/10.1002/ehf2.12564
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A giant mystery in giant cell myocarditis: navigating diagnosis, immunosuppression, and mechanical circulatory support

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