Treatment Strategies for High-Risk Localized and Locally Advanced and Oligometastatic Prostate Cancer
Despite the significant advances in the treatment of high-risk prostate cancer, patients with very high-risk features such as being locally advanced (clinical stage T3–4 or minimal nodal involvement), having a high Gleason pattern, or with oligometastasis may still have a poor prognosis despite aggr...
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doaj-e40cf0184e3246df9dd0a536b0cc30382021-09-09T13:41:09ZengMDPI AGCancers2072-66942021-09-01134470447010.3390/cancers13174470Treatment Strategies for High-Risk Localized and Locally Advanced and Oligometastatic Prostate CancerTomoyuki Makino0Kouji Izumi1Hiroaki Iwamoto2Atsushi Mizokami3Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, JapanDepartment of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, JapanDepartment of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, JapanDepartment of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, JapanDespite the significant advances in the treatment of high-risk prostate cancer, patients with very high-risk features such as being locally advanced (clinical stage T3–4 or minimal nodal involvement), having a high Gleason pattern, or with oligometastasis may still have a poor prognosis despite aggressive treatment. Multidisciplinary treatment with both local and systemic therapies is thought to be effective, however, unfortunately, there is still no standard treatment. However, in recent years, local definitive therapy using a combination of radiotherapy and androgen deprivation is being supported by several randomized clinical trials. This study reviews the current literature with a focus on the definition of very high-risk prostate cancer, the role of modern imaging, and its treatment options.https://www.mdpi.com/2072-6694/13/17/4470prostate cancerlocally advancedoligometastasisvery high-risk |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tomoyuki Makino Kouji Izumi Hiroaki Iwamoto Atsushi Mizokami |
spellingShingle |
Tomoyuki Makino Kouji Izumi Hiroaki Iwamoto Atsushi Mizokami Treatment Strategies for High-Risk Localized and Locally Advanced and Oligometastatic Prostate Cancer Cancers prostate cancer locally advanced oligometastasis very high-risk |
author_facet |
Tomoyuki Makino Kouji Izumi Hiroaki Iwamoto Atsushi Mizokami |
author_sort |
Tomoyuki Makino |
title |
Treatment Strategies for High-Risk Localized and Locally Advanced and Oligometastatic Prostate Cancer |
title_short |
Treatment Strategies for High-Risk Localized and Locally Advanced and Oligometastatic Prostate Cancer |
title_full |
Treatment Strategies for High-Risk Localized and Locally Advanced and Oligometastatic Prostate Cancer |
title_fullStr |
Treatment Strategies for High-Risk Localized and Locally Advanced and Oligometastatic Prostate Cancer |
title_full_unstemmed |
Treatment Strategies for High-Risk Localized and Locally Advanced and Oligometastatic Prostate Cancer |
title_sort |
treatment strategies for high-risk localized and locally advanced and oligometastatic prostate cancer |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2021-09-01 |
description |
Despite the significant advances in the treatment of high-risk prostate cancer, patients with very high-risk features such as being locally advanced (clinical stage T3–4 or minimal nodal involvement), having a high Gleason pattern, or with oligometastasis may still have a poor prognosis despite aggressive treatment. Multidisciplinary treatment with both local and systemic therapies is thought to be effective, however, unfortunately, there is still no standard treatment. However, in recent years, local definitive therapy using a combination of radiotherapy and androgen deprivation is being supported by several randomized clinical trials. This study reviews the current literature with a focus on the definition of very high-risk prostate cancer, the role of modern imaging, and its treatment options. |
topic |
prostate cancer locally advanced oligometastasis very high-risk |
url |
https://www.mdpi.com/2072-6694/13/17/4470 |
work_keys_str_mv |
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1717760681601662976 |