Influence of the Tumor Microenvironment on NK Cell Function in Solid Tumors

Influence of the Tumor Microenvironment on NK Cell Function in Solid Tumors

Natural killer (NK) cells are a population of innate lymphoid cells playing a pivotal role in host immune responses against infection and tumor growth. These cells have a powerful cytotoxic activity orchestrated by an intricate network of inhibitory and activating signals. The importance of NK cells...

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Bibliographic Details
Main Authors: Ombretta Melaiu, Valeria Lucarini, Loredana Cifaldi, Doriana Fruci
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
natural killer cells
tumor microenvironment
solid tumors
immune checkpoint inhibitors
cellular metabolism
cancer stem cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03038/full

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