The Geriatric Nutritional Risk Index Predicts Survival in Elderly Esophageal Squamous Cell Carcinoma Patients with Radiotherapy.
The impact of nutritional status on survival among elderly esophageal squamous cell carcinoma (ESCC) patients undergoing radiotherapy is unclear. In this study, we aimed at validating the performance of the geriatric nutritional risk index (GNRI) in predicting overall survival time in elderly ESCC p...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4873221?pdf=render |
id |
doaj-e41b1b98bd5e4170ae0e33584ec51871 |
---|---|
record_format |
Article |
spelling |
doaj-e41b1b98bd5e4170ae0e33584ec518712020-11-25T00:06:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01115e015590310.1371/journal.pone.0155903The Geriatric Nutritional Risk Index Predicts Survival in Elderly Esophageal Squamous Cell Carcinoma Patients with Radiotherapy.Yacong BoKunlun WangYang LiuJie YouHan CuiYiwei ZhuQuanjun LuLing YuanThe impact of nutritional status on survival among elderly esophageal squamous cell carcinoma (ESCC) patients undergoing radiotherapy is unclear. In this study, we aimed at validating the performance of the geriatric nutritional risk index (GNRI) in predicting overall survival time in elderly ESCC patients with radiotherapy. A retrospective cohort study was conducted on 239 ESCC patients aged 60 and over admitted consecutively from January 2008 to November 2014 in the Department of Radiotherapy, Henan Tumor Hospital (Affiliated Tumor Hospital of Zhengzhou University), Zhengzhou, Henan, China. All patients were subjected to nutritional screening using GNRI, and were followed for the occurrence of lymphatic node metastasis, radiation complication and mortality. The Kaplan-Meier method with Log-rank test was used to estimate survival curves. Univariable Cox regression analysis was used to identify variables associated with overall survival time. Among the 239 patients, 184 patients (76.9%) took no nutritional risk, 32 patients (13.4%) took moderate risk of malnutrition, and 23 patients (9.7%) took a high risk of malnutrition. Univariable Cox regression showed that both high nutritional risk group and moderate nutritional risk group were significantly less likely to survive than no nutritional risk patients (hazard ratio (HR) = 1.688, 95% confidence interval (CI) = 1.019-2.798 for moderate risk group, and HR = 2.699, 95% CI = 1.512-4.819 for high risk group, respectively). The GNRI is an independent prognostic factor for overall survival time in elderly ESCC patients with radiotherapy. A GNRI ≤98 can be suggested as an indicator of surviving less.http://europepmc.org/articles/PMC4873221?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yacong Bo Kunlun Wang Yang Liu Jie You Han Cui Yiwei Zhu Quanjun Lu Ling Yuan |
spellingShingle |
Yacong Bo Kunlun Wang Yang Liu Jie You Han Cui Yiwei Zhu Quanjun Lu Ling Yuan The Geriatric Nutritional Risk Index Predicts Survival in Elderly Esophageal Squamous Cell Carcinoma Patients with Radiotherapy. PLoS ONE |
author_facet |
Yacong Bo Kunlun Wang Yang Liu Jie You Han Cui Yiwei Zhu Quanjun Lu Ling Yuan |
author_sort |
Yacong Bo |
title |
The Geriatric Nutritional Risk Index Predicts Survival in Elderly Esophageal Squamous Cell Carcinoma Patients with Radiotherapy. |
title_short |
The Geriatric Nutritional Risk Index Predicts Survival in Elderly Esophageal Squamous Cell Carcinoma Patients with Radiotherapy. |
title_full |
The Geriatric Nutritional Risk Index Predicts Survival in Elderly Esophageal Squamous Cell Carcinoma Patients with Radiotherapy. |
title_fullStr |
The Geriatric Nutritional Risk Index Predicts Survival in Elderly Esophageal Squamous Cell Carcinoma Patients with Radiotherapy. |
title_full_unstemmed |
The Geriatric Nutritional Risk Index Predicts Survival in Elderly Esophageal Squamous Cell Carcinoma Patients with Radiotherapy. |
title_sort |
geriatric nutritional risk index predicts survival in elderly esophageal squamous cell carcinoma patients with radiotherapy. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
The impact of nutritional status on survival among elderly esophageal squamous cell carcinoma (ESCC) patients undergoing radiotherapy is unclear. In this study, we aimed at validating the performance of the geriatric nutritional risk index (GNRI) in predicting overall survival time in elderly ESCC patients with radiotherapy. A retrospective cohort study was conducted on 239 ESCC patients aged 60 and over admitted consecutively from January 2008 to November 2014 in the Department of Radiotherapy, Henan Tumor Hospital (Affiliated Tumor Hospital of Zhengzhou University), Zhengzhou, Henan, China. All patients were subjected to nutritional screening using GNRI, and were followed for the occurrence of lymphatic node metastasis, radiation complication and mortality. The Kaplan-Meier method with Log-rank test was used to estimate survival curves. Univariable Cox regression analysis was used to identify variables associated with overall survival time. Among the 239 patients, 184 patients (76.9%) took no nutritional risk, 32 patients (13.4%) took moderate risk of malnutrition, and 23 patients (9.7%) took a high risk of malnutrition. Univariable Cox regression showed that both high nutritional risk group and moderate nutritional risk group were significantly less likely to survive than no nutritional risk patients (hazard ratio (HR) = 1.688, 95% confidence interval (CI) = 1.019-2.798 for moderate risk group, and HR = 2.699, 95% CI = 1.512-4.819 for high risk group, respectively). The GNRI is an independent prognostic factor for overall survival time in elderly ESCC patients with radiotherapy. A GNRI ≤98 can be suggested as an indicator of surviving less. |
url |
http://europepmc.org/articles/PMC4873221?pdf=render |
work_keys_str_mv |
AT yacongbo thegeriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT kunlunwang thegeriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT yangliu thegeriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT jieyou thegeriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT hancui thegeriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT yiweizhu thegeriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT quanjunlu thegeriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT lingyuan thegeriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT yacongbo geriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT kunlunwang geriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT yangliu geriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT jieyou geriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT hancui geriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT yiweizhu geriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT quanjunlu geriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy AT lingyuan geriatricnutritionalriskindexpredictssurvivalinelderlyesophagealsquamouscellcarcinomapatientswithradiotherapy |
_version_ |
1725422322511249408 |