Epigenetic Changes in Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance that appears or is for the first time diagnosed during pregnancy. It can lead to many complications in the mother and in the offspring, so diagnostics and management of GDM are important to avoid adverse pregnancy outcomes. E...
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doaj-e41f08cf3f4f49e2ab79406b3810ff6c2021-07-23T13:46:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-01227649764910.3390/ijms22147649Epigenetic Changes in Gestational Diabetes MellitusDominik Franciszek Dłuski0Ewa Wolińska1Maciej Skrzypczak2Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, Street: Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Pathology, Medical University of Warsaw, Street: Żwirki i Wigury 61, 02-091 Warsaw, PolandII Chair and Department of Gynecology, Medical University of Lublin, Street: Jaczewskiego 8, 20-954 Lublin, PolandGestational diabetes mellitus (GDM) is defined as carbohydrate intolerance that appears or is for the first time diagnosed during pregnancy. It can lead to many complications in the mother and in the offspring, so diagnostics and management of GDM are important to avoid adverse pregnancy outcomes. Epigenetic studies revealed the different methylation status of genes in pregnancies with GDM compared to pregnancies without GDM. A growing body of evidence shows that the GDM can affect not only the course of the pregnancy, but also the development of the offspring, thus contributing to long-term effects and adverse health outcomes of the progeny. Epigenetic changes occur through histone modification, DNA methylation, and disrupted function of non-coding ribonucleic acid (ncRNA) including microRNAs (miRNAs). In this review, we focus on the recent knowledge about epigenetic changes in GDM. The analysis of this topic may help us to understand pathophysiological mechanisms in GDM and find a solution to prevent their consequences.https://www.mdpi.com/1422-0067/22/14/7649gestational diabetes mellitusDNA methylationepigeneticshistone modificationnon-coding RNAs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dominik Franciszek Dłuski Ewa Wolińska Maciej Skrzypczak |
spellingShingle |
Dominik Franciszek Dłuski Ewa Wolińska Maciej Skrzypczak Epigenetic Changes in Gestational Diabetes Mellitus International Journal of Molecular Sciences gestational diabetes mellitus DNA methylation epigenetics histone modification non-coding RNAs |
author_facet |
Dominik Franciszek Dłuski Ewa Wolińska Maciej Skrzypczak |
author_sort |
Dominik Franciszek Dłuski |
title |
Epigenetic Changes in Gestational Diabetes Mellitus |
title_short |
Epigenetic Changes in Gestational Diabetes Mellitus |
title_full |
Epigenetic Changes in Gestational Diabetes Mellitus |
title_fullStr |
Epigenetic Changes in Gestational Diabetes Mellitus |
title_full_unstemmed |
Epigenetic Changes in Gestational Diabetes Mellitus |
title_sort |
epigenetic changes in gestational diabetes mellitus |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-07-01 |
description |
Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance that appears or is for the first time diagnosed during pregnancy. It can lead to many complications in the mother and in the offspring, so diagnostics and management of GDM are important to avoid adverse pregnancy outcomes. Epigenetic studies revealed the different methylation status of genes in pregnancies with GDM compared to pregnancies without GDM. A growing body of evidence shows that the GDM can affect not only the course of the pregnancy, but also the development of the offspring, thus contributing to long-term effects and adverse health outcomes of the progeny. Epigenetic changes occur through histone modification, DNA methylation, and disrupted function of non-coding ribonucleic acid (ncRNA) including microRNAs (miRNAs). In this review, we focus on the recent knowledge about epigenetic changes in GDM. The analysis of this topic may help us to understand pathophysiological mechanisms in GDM and find a solution to prevent their consequences. |
topic |
gestational diabetes mellitus DNA methylation epigenetics histone modification non-coding RNAs |
url |
https://www.mdpi.com/1422-0067/22/14/7649 |
work_keys_str_mv |
AT dominikfranciszekdłuski epigeneticchangesingestationaldiabetesmellitus AT ewawolinska epigeneticchangesingestationaldiabetesmellitus AT maciejskrzypczak epigeneticchangesingestationaldiabetesmellitus |
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1721287848606302208 |