The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing
Overweight and obesity are major problems in today’s society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditio...
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doaj-e4232580898e406288d375729ec620492020-11-24T21:32:25ZengMDPI AGGenes2073-44252014-09-015492695610.3390/genes5040926genes5040926The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound HealingJoão Moura0Elisabet Børsheim1Eugenia Carvalho2Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-517, PortugalArkansas Children's Nutrition Center, Little Rock, Arkansas, AR 72202, USACenter for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-517, PortugalOverweight and obesity are major problems in today’s society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the most important complications include macrovascular abnormalities, e.g., heart disease and atherosclerosis, and microvascular abnormalities, e.g., retinopathy, nephropathy and neuropathy, in particular diabetic foot ulceration. The highly conserved endogenous small non-coding RNA molecules, the micro RNAs (miRNAs) have in recent years been found to be involved in a number of biological processes, including the pathogenesis of disease. Their main function is to regulate post-transcriptional gene expression by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation, suppression of translation or even gene activation. These molecules are promising therapeutic targets and demonstrate great potential as diagnostic biomarkers for disease. This review aims to describe the most recent findings regarding the important roles of miRNAs in diabetes and its complications, with special attention given to the different phases of diabetic wound healing.http://www.mdpi.com/2073-4425/5/4/926microRNAdiabetesmacrovascular and microvascular complicationsskinwound healinginflammationvascular diseasediagnostic biomarkerstherapeutic targets |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
João Moura Elisabet Børsheim Eugenia Carvalho |
spellingShingle |
João Moura Elisabet Børsheim Eugenia Carvalho The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing Genes microRNA diabetes macrovascular and microvascular complications skin wound healing inflammation vascular disease diagnostic biomarkers therapeutic targets |
author_facet |
João Moura Elisabet Børsheim Eugenia Carvalho |
author_sort |
João Moura |
title |
The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing |
title_short |
The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing |
title_full |
The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing |
title_fullStr |
The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing |
title_full_unstemmed |
The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing |
title_sort |
role of micrornas in diabetic complications—special emphasis on wound healing |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2014-09-01 |
description |
Overweight and obesity are major problems in today’s society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the most important complications include macrovascular abnormalities, e.g., heart disease and atherosclerosis, and microvascular abnormalities, e.g., retinopathy, nephropathy and neuropathy, in particular diabetic foot ulceration. The highly conserved endogenous small non-coding RNA molecules, the micro RNAs (miRNAs) have in recent years been found to be involved in a number of biological processes, including the pathogenesis of disease. Their main function is to regulate post-transcriptional gene expression by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation, suppression of translation or even gene activation. These molecules are promising therapeutic targets and demonstrate great potential as diagnostic biomarkers for disease. This review aims to describe the most recent findings regarding the important roles of miRNAs in diabetes and its complications, with special attention given to the different phases of diabetic wound healing. |
topic |
microRNA diabetes macrovascular and microvascular complications skin wound healing inflammation vascular disease diagnostic biomarkers therapeutic targets |
url |
http://www.mdpi.com/2073-4425/5/4/926 |
work_keys_str_mv |
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_version_ |
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