A cell-based fluorescent glucose transporter assay for SGLT2 inhibitor discovery

A cell-based fluorescent glucose transporter assay for SGLT2 inhibitor discovery

The sodium/glucose cotransporter 2 (SGLT2) is responsible for the majority of glucose reabsorption in the kidney, and currently, SGLT2 inhibitors are considered as promising hypoglycemic agents for the treatment of type 2 diabetes mellitus. By constructing CHO cell lines that stably express the huma...

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Bibliographic Details
Main Authors: Yi Huan, Linyi Li, Quan Liu, Shuainan Liu, Zhufang Shen
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
SGLT2 inhibitor
NBDG
Type 2 diabetes mellitus
Kidney
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383513000129

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