Uric acid and incident atrial fibrillation of 14 years population‐based cohort study: The Suita Study
Abstract Background Higher baseline uric acid (UA) was significantly associated with higher atrial fibrillation (AF) incidence in Japanese women. However, no prospective study is evident in the association between UA and incident AF in Japanese urban residents. Methods A total of 6863 participants (...
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doaj-e42e47b410a14070bd48c605b4333da32021-10-01T13:30:38ZengWileyJournal of Arrhythmia1880-42761883-21482021-10-013751215121910.1002/joa3.12612Uric acid and incident atrial fibrillation of 14 years population‐based cohort study: The Suita StudyTakashi Kobayashi0Yoshihiro Kokubo1Aya Higashiyama2Makoto Watanabe3Yoko M. Nakao4Shiro Kamakura5Kengo Kusano6Yoshihiro Miyamoto7Department of Preventive Cardiology National Cerebral and Cardiovascular Center Suita JapanDepartment of Preventive Cardiology National Cerebral and Cardiovascular Center Suita JapanDepartment of Preventive Cardiology National Cerebral and Cardiovascular Center Suita JapanDepartment of Preventive Cardiology National Cerebral and Cardiovascular Center Suita JapanDepartment of Preventive Cardiology National Cerebral and Cardiovascular Center Suita JapanDepartment of Cardiovascular Medicine National Cerebral and Cardiovascular Center Suita JapanDepartment of Cardiovascular Medicine National Cerebral and Cardiovascular Center Suita JapanDepartment of Preventive Cardiology National Cerebral and Cardiovascular Center Suita JapanAbstract Background Higher baseline uric acid (UA) was significantly associated with higher atrial fibrillation (AF) incidence in Japanese women. However, no prospective study is evident in the association between UA and incident AF in Japanese urban residents. Methods A total of 6863 participants (aged 30‐79 years; 47% men) without prior AF were followed for 13.9 years on average in the Suita Study. According to the UA categories, cox proportional hazards regression models were used to estimating the Hazard Ratios (HRs) and 95% confidence intervals (CIs) for incident AF. Results During 95178 person‐years of follow‐up, we observed 311 cases of incident AF (204 cases in men and 107 cases in women). Compared to the subjects with UA of 4.0‐4.9 mg/dL, multivariable‐adjusted HR (95% CIs) of incident AF was 1.50 (1.01‐2.25) (P = .047) for the subjects with UA ≥7.0 mg/dL. Conclusion High UA was associated with an increased risk for incident AF in the Japanese population.https://doi.org/10.1002/joa3.12612atrial fibrillationprospective studyuric acid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takashi Kobayashi Yoshihiro Kokubo Aya Higashiyama Makoto Watanabe Yoko M. Nakao Shiro Kamakura Kengo Kusano Yoshihiro Miyamoto |
spellingShingle |
Takashi Kobayashi Yoshihiro Kokubo Aya Higashiyama Makoto Watanabe Yoko M. Nakao Shiro Kamakura Kengo Kusano Yoshihiro Miyamoto Uric acid and incident atrial fibrillation of 14 years population‐based cohort study: The Suita Study Journal of Arrhythmia atrial fibrillation prospective study uric acid |
author_facet |
Takashi Kobayashi Yoshihiro Kokubo Aya Higashiyama Makoto Watanabe Yoko M. Nakao Shiro Kamakura Kengo Kusano Yoshihiro Miyamoto |
author_sort |
Takashi Kobayashi |
title |
Uric acid and incident atrial fibrillation of 14 years population‐based cohort study: The Suita Study |
title_short |
Uric acid and incident atrial fibrillation of 14 years population‐based cohort study: The Suita Study |
title_full |
Uric acid and incident atrial fibrillation of 14 years population‐based cohort study: The Suita Study |
title_fullStr |
Uric acid and incident atrial fibrillation of 14 years population‐based cohort study: The Suita Study |
title_full_unstemmed |
Uric acid and incident atrial fibrillation of 14 years population‐based cohort study: The Suita Study |
title_sort |
uric acid and incident atrial fibrillation of 14 years population‐based cohort study: the suita study |
publisher |
Wiley |
series |
Journal of Arrhythmia |
issn |
1880-4276 1883-2148 |
publishDate |
2021-10-01 |
description |
Abstract Background Higher baseline uric acid (UA) was significantly associated with higher atrial fibrillation (AF) incidence in Japanese women. However, no prospective study is evident in the association between UA and incident AF in Japanese urban residents. Methods A total of 6863 participants (aged 30‐79 years; 47% men) without prior AF were followed for 13.9 years on average in the Suita Study. According to the UA categories, cox proportional hazards regression models were used to estimating the Hazard Ratios (HRs) and 95% confidence intervals (CIs) for incident AF. Results During 95178 person‐years of follow‐up, we observed 311 cases of incident AF (204 cases in men and 107 cases in women). Compared to the subjects with UA of 4.0‐4.9 mg/dL, multivariable‐adjusted HR (95% CIs) of incident AF was 1.50 (1.01‐2.25) (P = .047) for the subjects with UA ≥7.0 mg/dL. Conclusion High UA was associated with an increased risk for incident AF in the Japanese population. |
topic |
atrial fibrillation prospective study uric acid |
url |
https://doi.org/10.1002/joa3.12612 |
work_keys_str_mv |
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