Dietary Supplementation with Oleum Cinnamomi Improves Intestinal Functions in Piglets
The present study was to determine the efficacy of dietary supplementation with oleum cinnamomi (OCM) on growth performance and intestinal functions in piglets. Sixteen piglets (24-day-old) were randomly assigned to the control or OCM groups. Piglets in the control group were fed a basal diet, where...
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doaj-e439559a4d8445e4b84c30bf8094ca0d2020-11-24T21:00:39ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-04-01195128410.3390/ijms19051284ijms19051284Dietary Supplementation with Oleum Cinnamomi Improves Intestinal Functions in PigletsDan Yi0Qiuhong Fang1Yongqing Hou2Lei Wang3Haiwang Xu4Tao Wu5Joshua Gong6Guoyao Wu7Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, ChinaHubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, ChinaHubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, ChinaHubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, ChinaHubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, ChinaHubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, ChinaGuelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, CanadaHubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, ChinaThe present study was to determine the efficacy of dietary supplementation with oleum cinnamomi (OCM) on growth performance and intestinal functions in piglets. Sixteen piglets (24-day-old) were randomly assigned to the control or OCM groups. Piglets in the control group were fed a basal diet, whereas piglets in the OCM group were fed the basal diet supplemented with 50 mg/kg OCM. On day 20 of the trial, blood samples and intestinal tissues were obtained from piglets. Compared with the control group, dietary OCM supplementation increased (p < 0.05) average daily feed intake, plasma insulin levels, villus width and villous surface area in the duodenum and jejunum, DNA levels and RNA/DNA ratios in the ileum, the abundance of Enterococcus genus and Lactobacillus genus in caecum digesta, mRNA levels for epithelial growth factor receptor (EGFR), Ras, extracellular signal-regulated kinase 1/2 (Erk1/2), b-cell lymphoma-extra large (Bcl-xL), villin, junctional adhesion molecule A (JAM-A), myxovirus resistance (MX) 1, MX2 and regenerating islet-derived protein 3 gamma (REG3G), and protein abundances of Ras and claudin-1, but decreased (p < 0.05) diarrhoea incidence; the abundances of Enterobacteriaceae family, Enterococcus genus, Lactobacillus genus, Bifidobacterium genus, and Clostrium coccoides in the colon digesta, and AMP-activated protein kinase (AMPK) mRNA levels and caspase-3 protein abundance in the jejunal mucosa of piglets. Taken together, these data indicate that dietary OCM supplementation modulates intestinal microbiota and improves intestinal function in weanling pigs. OCM is an effective feed additive and alternative to feed antibiotics for improving intestinal health in swine.http://www.mdpi.com/1422-0067/19/5/1284oleum cinnamomigrowth performanceintestinal functionpiglets |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dan Yi Qiuhong Fang Yongqing Hou Lei Wang Haiwang Xu Tao Wu Joshua Gong Guoyao Wu |
spellingShingle |
Dan Yi Qiuhong Fang Yongqing Hou Lei Wang Haiwang Xu Tao Wu Joshua Gong Guoyao Wu Dietary Supplementation with Oleum Cinnamomi Improves Intestinal Functions in Piglets International Journal of Molecular Sciences oleum cinnamomi growth performance intestinal function piglets |
author_facet |
Dan Yi Qiuhong Fang Yongqing Hou Lei Wang Haiwang Xu Tao Wu Joshua Gong Guoyao Wu |
author_sort |
Dan Yi |
title |
Dietary Supplementation with Oleum Cinnamomi Improves Intestinal Functions in Piglets |
title_short |
Dietary Supplementation with Oleum Cinnamomi Improves Intestinal Functions in Piglets |
title_full |
Dietary Supplementation with Oleum Cinnamomi Improves Intestinal Functions in Piglets |
title_fullStr |
Dietary Supplementation with Oleum Cinnamomi Improves Intestinal Functions in Piglets |
title_full_unstemmed |
Dietary Supplementation with Oleum Cinnamomi Improves Intestinal Functions in Piglets |
title_sort |
dietary supplementation with oleum cinnamomi improves intestinal functions in piglets |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-04-01 |
description |
The present study was to determine the efficacy of dietary supplementation with oleum cinnamomi (OCM) on growth performance and intestinal functions in piglets. Sixteen piglets (24-day-old) were randomly assigned to the control or OCM groups. Piglets in the control group were fed a basal diet, whereas piglets in the OCM group were fed the basal diet supplemented with 50 mg/kg OCM. On day 20 of the trial, blood samples and intestinal tissues were obtained from piglets. Compared with the control group, dietary OCM supplementation increased (p < 0.05) average daily feed intake, plasma insulin levels, villus width and villous surface area in the duodenum and jejunum, DNA levels and RNA/DNA ratios in the ileum, the abundance of Enterococcus genus and Lactobacillus genus in caecum digesta, mRNA levels for epithelial growth factor receptor (EGFR), Ras, extracellular signal-regulated kinase 1/2 (Erk1/2), b-cell lymphoma-extra large (Bcl-xL), villin, junctional adhesion molecule A (JAM-A), myxovirus resistance (MX) 1, MX2 and regenerating islet-derived protein 3 gamma (REG3G), and protein abundances of Ras and claudin-1, but decreased (p < 0.05) diarrhoea incidence; the abundances of Enterobacteriaceae family, Enterococcus genus, Lactobacillus genus, Bifidobacterium genus, and Clostrium coccoides in the colon digesta, and AMP-activated protein kinase (AMPK) mRNA levels and caspase-3 protein abundance in the jejunal mucosa of piglets. Taken together, these data indicate that dietary OCM supplementation modulates intestinal microbiota and improves intestinal function in weanling pigs. OCM is an effective feed additive and alternative to feed antibiotics for improving intestinal health in swine. |
topic |
oleum cinnamomi growth performance intestinal function piglets |
url |
http://www.mdpi.com/1422-0067/19/5/1284 |
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