Reference Tracts and Generative Models for Brain White Matter Tractography
Background: Probabilistic neighborhood tractography aims to automatically segment brain white matter tracts from diffusion magnetic resonance imaging (dMRI) data in different individuals. It uses reference tracts as priors for the shape and length of the tract, and matching models that describe typi...
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doaj-e43f9c0b251a44b3bf3216188402ea042020-11-25T01:42:01ZengMDPI AGJournal of Imaging2313-433X2017-12-0141810.3390/jimaging4010008jimaging4010008Reference Tracts and Generative Models for Brain White Matter TractographySusana Muñoz Maniega0Mark E. Bastin1Ian J. Deary2Joanna M. Wardlaw3Jonathan D. Clayden4Department of Neuroimaging Sciences and Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH16 4SB, UKDepartment of Neuroimaging Sciences and Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH16 4SB, UKDepartment of Psychology and Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UKDepartment of Neuroimaging Sciences, Centre for Cognitive Ageing and Cognitive Epidemiology and UK Dementia Research Institute at the University of Edinburgh, University of Edinburgh, Edinburgh EH16 4SB, UKUCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UKBackground: Probabilistic neighborhood tractography aims to automatically segment brain white matter tracts from diffusion magnetic resonance imaging (dMRI) data in different individuals. It uses reference tracts as priors for the shape and length of the tract, and matching models that describe typical deviations from these. We evaluated new reference tracts and matching models derived from dMRI data acquired from 80 healthy volunteers, aged 25–64 years. Methods: The new reference tracts and models were tested in 50 healthy older people, aged 71.8 ± 0.4 years. The matching models were further assessed by sampling and visualizing synthetic tracts derived from them. Results: We found that data-generated reference tracts improved the success rate of automatic white matter tract segmentations. We observed an increased rate of visually acceptable tracts, and decreased variation in quantitative parameters when using this approach. Sampling from the matching models demonstrated their quality, independently of the testing data. Conclusions: We have improved the automatic segmentation of brain white matter tracts, and demonstrated that matching models can be successfully transferred to novel data. In many cases, this will bypass the need for training data and make the use of probabilistic neighborhood tractography in small testing datasets newly practicable.https://www.mdpi.com/2313-433X/4/1/8MRIbrainwhite matterunsupervised segmentationtractography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Susana Muñoz Maniega Mark E. Bastin Ian J. Deary Joanna M. Wardlaw Jonathan D. Clayden |
spellingShingle |
Susana Muñoz Maniega Mark E. Bastin Ian J. Deary Joanna M. Wardlaw Jonathan D. Clayden Reference Tracts and Generative Models for Brain White Matter Tractography Journal of Imaging MRI brain white matter unsupervised segmentation tractography |
author_facet |
Susana Muñoz Maniega Mark E. Bastin Ian J. Deary Joanna M. Wardlaw Jonathan D. Clayden |
author_sort |
Susana Muñoz Maniega |
title |
Reference Tracts and Generative Models for Brain White Matter Tractography |
title_short |
Reference Tracts and Generative Models for Brain White Matter Tractography |
title_full |
Reference Tracts and Generative Models for Brain White Matter Tractography |
title_fullStr |
Reference Tracts and Generative Models for Brain White Matter Tractography |
title_full_unstemmed |
Reference Tracts and Generative Models for Brain White Matter Tractography |
title_sort |
reference tracts and generative models for brain white matter tractography |
publisher |
MDPI AG |
series |
Journal of Imaging |
issn |
2313-433X |
publishDate |
2017-12-01 |
description |
Background: Probabilistic neighborhood tractography aims to automatically segment brain white matter tracts from diffusion magnetic resonance imaging (dMRI) data in different individuals. It uses reference tracts as priors for the shape and length of the tract, and matching models that describe typical deviations from these. We evaluated new reference tracts and matching models derived from dMRI data acquired from 80 healthy volunteers, aged 25–64 years. Methods: The new reference tracts and models were tested in 50 healthy older people, aged 71.8 ± 0.4 years. The matching models were further assessed by sampling and visualizing synthetic tracts derived from them. Results: We found that data-generated reference tracts improved the success rate of automatic white matter tract segmentations. We observed an increased rate of visually acceptable tracts, and decreased variation in quantitative parameters when using this approach. Sampling from the matching models demonstrated their quality, independently of the testing data. Conclusions: We have improved the automatic segmentation of brain white matter tracts, and demonstrated that matching models can be successfully transferred to novel data. In many cases, this will bypass the need for training data and make the use of probabilistic neighborhood tractography in small testing datasets newly practicable. |
topic |
MRI brain white matter unsupervised segmentation tractography |
url |
https://www.mdpi.com/2313-433X/4/1/8 |
work_keys_str_mv |
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