Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms
Abstract Gastrointestinal symptoms are frequent in acute adrenal insufficiency. Although digestive symptoms can significantly reduce quality of life, they are rarely described in patients with treated chronic adrenal insufficiency (CAI). We aimed to characterize digestive symptoms in CAI patients. W...
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doaj-e4411dbbfead4d89a46951eed925a1a42021-04-18T11:35:09ZengNature Publishing GroupScientific Reports2045-23222021-04-011111810.1038/s41598-021-87158-2Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptomsL. Quénéhervé0D. Drui1J. Blin2M. Péré3E. Coron4G. Barbara5M. R. Barbaro6B. Cariou7M. Neunlist8D. Masson9K. Bach-Ngohou10INSERM, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, University of NantesDepartment of Endocrinology, l’Institut du Thorax, CHU NantesINSERM, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, University of NantesBiostatistics Unit, Research Board, CHU NantesINSERM, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, University of NantesDepartment of Medical and Surgical Sciences, Centre for Applied Biomedical Research, University of BolognaDepartment of Medical and Surgical Sciences, Centre for Applied Biomedical Research, University of BolognaDepartment of Endocrinology, CNRS, INSERM, l’Institut du Thorax, CHU Nantes, Université de NantesINSERM, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, University of NantesINSERM, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, University of NantesINSERM, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, University of NantesAbstract Gastrointestinal symptoms are frequent in acute adrenal insufficiency. Although digestive symptoms can significantly reduce quality of life, they are rarely described in patients with treated chronic adrenal insufficiency (CAI). We aimed to characterize digestive symptoms in CAI patients. We used the section pertaining functional bowel disorders of the Rome IV questionnaire. A questionnaire was published on the website of the non-profit patient association “Adrenals” (NPPA of CAI patients) for five months. Information on demographics, characteristics of adrenal insufficiency, digestive symptoms and quality of life was collected. The relatives of CAI patients served as a control group. We analyzed responses of 33 control subjects and 119 patients (68 primary adrenal insufficiency (PAI), 30 secondary adrenal insufficiency (SAI) and 21 congenital adrenal hyperplasia (CAH)). Abdominal pain at least once a week over the past 3 months was reported by 40%, 47% and 33% of patients with PAI, SAI and CAH respectively versus 15% for the controls (p = 0.01). Symptoms were consistent with the Rome IV criteria for irritable bowel syndrome in 27%, 33% and 33% of patients respectively versus 6% for the controls (p < 0.0001). Quality of life was described as poor or very poor in 35%, 57% and 24% of patients respectively versus 5% for the controls (p < 0.0001). In conclusion, digestive symptoms are frequent and incapacitating in CAI patients and similar to symptoms of irritable bowel syndrome in 30% of CAI patients. Assessment and management of digestive symptoms should be considered a priority for physicians treating patients with CAI.https://doi.org/10.1038/s41598-021-87158-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
L. Quénéhervé D. Drui J. Blin M. Péré E. Coron G. Barbara M. R. Barbaro B. Cariou M. Neunlist D. Masson K. Bach-Ngohou |
spellingShingle |
L. Quénéhervé D. Drui J. Blin M. Péré E. Coron G. Barbara M. R. Barbaro B. Cariou M. Neunlist D. Masson K. Bach-Ngohou Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms Scientific Reports |
author_facet |
L. Quénéhervé D. Drui J. Blin M. Péré E. Coron G. Barbara M. R. Barbaro B. Cariou M. Neunlist D. Masson K. Bach-Ngohou |
author_sort |
L. Quénéhervé |
title |
Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms |
title_short |
Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms |
title_full |
Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms |
title_fullStr |
Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms |
title_full_unstemmed |
Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms |
title_sort |
digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-04-01 |
description |
Abstract Gastrointestinal symptoms are frequent in acute adrenal insufficiency. Although digestive symptoms can significantly reduce quality of life, they are rarely described in patients with treated chronic adrenal insufficiency (CAI). We aimed to characterize digestive symptoms in CAI patients. We used the section pertaining functional bowel disorders of the Rome IV questionnaire. A questionnaire was published on the website of the non-profit patient association “Adrenals” (NPPA of CAI patients) for five months. Information on demographics, characteristics of adrenal insufficiency, digestive symptoms and quality of life was collected. The relatives of CAI patients served as a control group. We analyzed responses of 33 control subjects and 119 patients (68 primary adrenal insufficiency (PAI), 30 secondary adrenal insufficiency (SAI) and 21 congenital adrenal hyperplasia (CAH)). Abdominal pain at least once a week over the past 3 months was reported by 40%, 47% and 33% of patients with PAI, SAI and CAH respectively versus 15% for the controls (p = 0.01). Symptoms were consistent with the Rome IV criteria for irritable bowel syndrome in 27%, 33% and 33% of patients respectively versus 6% for the controls (p < 0.0001). Quality of life was described as poor or very poor in 35%, 57% and 24% of patients respectively versus 5% for the controls (p < 0.0001). In conclusion, digestive symptoms are frequent and incapacitating in CAI patients and similar to symptoms of irritable bowel syndrome in 30% of CAI patients. Assessment and management of digestive symptoms should be considered a priority for physicians treating patients with CAI. |
url |
https://doi.org/10.1038/s41598-021-87158-2 |
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