Killing HIV-infected resting central memory CD4 T cells by targeting inhibitor of apoptosis proteins-inhibited autophagy
Dysfunction of CD4 + T cells by HIV infection can cause serious immune defects. Recently, Campbell and colleagues described an intriguing and simple therapeutic method for HIV-infected resting central memory CD4 + T cells (HIV-T CM ), dependently on inhibitor of apoptosis (IAP) family proteins-targe...
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2021-02-01
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Series: | Antiviral Chemistry & Chemotherapy |
Online Access: | https://doi.org/10.1177/2040206620980888 |
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doaj-e443f95479f8473d80b5ffa194ccc0af2021-02-10T04:04:58ZengSAGE PublishingAntiviral Chemistry & Chemotherapy2040-20662021-02-012910.1177/2040206620980888Killing HIV-infected resting central memory CD4 T cells by targeting inhibitor of apoptosis proteins-inhibited autophagyGang ZhangXing HuangDysfunction of CD4 + T cells by HIV infection can cause serious immune defects. Recently, Campbell and colleagues described an intriguing and simple therapeutic method for HIV-infected resting central memory CD4 + T cells (HIV-T CM ), dependently on inhibitor of apoptosis (IAP) family proteins-targeted and second mitochondria-derived activator of caspases (SMAC) mimetics-mediated apoptosis, which is only triggered in HIV-T CM and not uninfected ones. Autophagy induction and subsequent formation of a ripoptosome-like death signaling complex were observed after such treatment, which may partially explain the potential mechanism. However, the direct intracellular inhibitory effects of IAPs on autophagy, as well as the critical roles of autophagy in activating extracellular anti-infection immune responses, warrant further investigation. Thus, this pointer aims to provide potential alternative mechanisms and to suggest important avenues for follow-up study.https://doi.org/10.1177/2040206620980888 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gang Zhang Xing Huang |
spellingShingle |
Gang Zhang Xing Huang Killing HIV-infected resting central memory CD4 T cells by targeting inhibitor of apoptosis proteins-inhibited autophagy Antiviral Chemistry & Chemotherapy |
author_facet |
Gang Zhang Xing Huang |
author_sort |
Gang Zhang |
title |
Killing HIV-infected resting central memory CD4 T cells by targeting inhibitor of apoptosis proteins-inhibited autophagy |
title_short |
Killing HIV-infected resting central memory CD4 T cells by targeting inhibitor of apoptosis proteins-inhibited autophagy |
title_full |
Killing HIV-infected resting central memory CD4 T cells by targeting inhibitor of apoptosis proteins-inhibited autophagy |
title_fullStr |
Killing HIV-infected resting central memory CD4 T cells by targeting inhibitor of apoptosis proteins-inhibited autophagy |
title_full_unstemmed |
Killing HIV-infected resting central memory CD4 T cells by targeting inhibitor of apoptosis proteins-inhibited autophagy |
title_sort |
killing hiv-infected resting central memory cd4 t cells by targeting inhibitor of apoptosis proteins-inhibited autophagy |
publisher |
SAGE Publishing |
series |
Antiviral Chemistry & Chemotherapy |
issn |
2040-2066 |
publishDate |
2021-02-01 |
description |
Dysfunction of CD4 + T cells by HIV infection can cause serious immune defects. Recently, Campbell and colleagues described an intriguing and simple therapeutic method for HIV-infected resting central memory CD4 + T cells (HIV-T CM ), dependently on inhibitor of apoptosis (IAP) family proteins-targeted and second mitochondria-derived activator of caspases (SMAC) mimetics-mediated apoptosis, which is only triggered in HIV-T CM and not uninfected ones. Autophagy induction and subsequent formation of a ripoptosome-like death signaling complex were observed after such treatment, which may partially explain the potential mechanism. However, the direct intracellular inhibitory effects of IAPs on autophagy, as well as the critical roles of autophagy in activating extracellular anti-infection immune responses, warrant further investigation. Thus, this pointer aims to provide potential alternative mechanisms and to suggest important avenues for follow-up study. |
url |
https://doi.org/10.1177/2040206620980888 |
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AT gangzhang killinghivinfectedrestingcentralmemorycd4tcellsbytargetinginhibitorofapoptosisproteinsinhibitedautophagy AT xinghuang killinghivinfectedrestingcentralmemorycd4tcellsbytargetinginhibitorofapoptosisproteinsinhibitedautophagy |
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