Alphaherpesvirus-vectored vaccines against animal diseases: Current progress
Recombinant virus-vectored vaccines are novel agents that can effectively activate specific and nonspecific immunity, are multivalent and multieffective, and have high safety ratings. Animal alphaherpesviruses have a large genome, contain multiple nonessential regions that do not affect viral replic...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-08-01
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| Series: | Journal of Integrative Agriculture |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095311920631756 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yang HU Ming-shu WANG An-chun CHENG Ren-yong JIA Qiao YANG Ying WU Ma-feng LIU Xin-xin ZHAO De-kang ZHU Shun CHEN Sha-qiu ZHANG Yin WANG Qun GAO Xu-min OU Sai MAO Xing-jian WEN Zhi-wen XU Zheng-li CHEN Ling ZHU Qi-hui LUO Bin TIAN Lei-chang PAN Mujeeb Ur REHMAN Yun-ya LIU Yan-ling YU Ling ZHANG Xiao-yue CHEN |
| spellingShingle |
Yang HU Ming-shu WANG An-chun CHENG Ren-yong JIA Qiao YANG Ying WU Ma-feng LIU Xin-xin ZHAO De-kang ZHU Shun CHEN Sha-qiu ZHANG Yin WANG Qun GAO Xu-min OU Sai MAO Xing-jian WEN Zhi-wen XU Zheng-li CHEN Ling ZHU Qi-hui LUO Bin TIAN Lei-chang PAN Mujeeb Ur REHMAN Yun-ya LIU Yan-ling YU Ling ZHANG Xiao-yue CHEN Alphaherpesvirus-vectored vaccines against animal diseases: Current progress Journal of Integrative Agriculture recombinant vectored-vaccine recombinant alphaherpesviruses immunity gene-editing exogenous gene |
| author_facet |
Yang HU Ming-shu WANG An-chun CHENG Ren-yong JIA Qiao YANG Ying WU Ma-feng LIU Xin-xin ZHAO De-kang ZHU Shun CHEN Sha-qiu ZHANG Yin WANG Qun GAO Xu-min OU Sai MAO Xing-jian WEN Zhi-wen XU Zheng-li CHEN Ling ZHU Qi-hui LUO Bin TIAN Lei-chang PAN Mujeeb Ur REHMAN Yun-ya LIU Yan-ling YU Ling ZHANG Xiao-yue CHEN |
| author_sort |
Yang HU |
| title |
Alphaherpesvirus-vectored vaccines against animal diseases: Current progress |
| title_short |
Alphaherpesvirus-vectored vaccines against animal diseases: Current progress |
| title_full |
Alphaherpesvirus-vectored vaccines against animal diseases: Current progress |
| title_fullStr |
Alphaherpesvirus-vectored vaccines against animal diseases: Current progress |
| title_full_unstemmed |
Alphaherpesvirus-vectored vaccines against animal diseases: Current progress |
| title_sort |
alphaherpesvirus-vectored vaccines against animal diseases: current progress |
| publisher |
Elsevier |
| series |
Journal of Integrative Agriculture |
| issn |
2095-3119 |
| publishDate |
2020-08-01 |
| description |
Recombinant virus-vectored vaccines are novel agents that can effectively activate specific and nonspecific immunity, are multivalent and multieffective, and have high safety ratings. Animal alphaherpesviruses have a large genome, contain multiple nonessential regions that do not affect viral replication and are capable of accepting the insertion of an exogenous gene and expressing the antigen protein. Furthermore, animal alphaherpesviruses have a wide host spectrum, can replicate in the host and continuously stimulate the animal to produce immunity to the corresponding pathogen, thus making them ideal carriers for recombinant virus-vectored vaccines. With the development of gene-editing technology, recombinant viruses capable of expressing foreign genes can be constructed by various methods. Currently, studies on recombinant virus-vectored vaccines constructed based on animal alphaherpesviruses have involved poultry, pigs, cattle, sheep, and companion animals. Studies have shown that the construction of recombinant animal alphaherpesviruses enables the acquisition of immunity to multiple diseases. This article mainly summarizes the current progress on animal alphaherpesvirus-vectored vaccines, aiming to provide reference for the development of new animal alphaherpesvirus-vectored vaccines. |
| topic |
recombinant vectored-vaccine recombinant alphaherpesviruses immunity gene-editing exogenous gene |
| url |
http://www.sciencedirect.com/science/article/pii/S2095311920631756 |
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1721390320199925760 |
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doaj-e444b48b550b485e9bc12b331e2c14902021-06-08T04:42:24ZengElsevierJournal of Integrative Agriculture2095-31192020-08-0119819281940Alphaherpesvirus-vectored vaccines against animal diseases: Current progressYang HU0Ming-shu WANG1An-chun CHENG2Ren-yong JIA3Qiao YANG4Ying WU5Ma-feng LIU6Xin-xin ZHAO7De-kang ZHU8Shun CHEN9Sha-qiu ZHANG10Yin WANG11Qun GAO12Xu-min OU13Sai MAO14Xing-jian WEN15Zhi-wen XU16Zheng-li CHEN17Ling ZHU18Qi-hui LUO19Bin TIAN20Lei-chang PAN21Mujeeb Ur REHMAN22Yun-ya LIU23Yan-ling YU24Ling ZHANG25Xiao-yue CHEN26Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Correspondence HU YangInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Correspondence CHENG An-chunInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China; Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.ChinaRecombinant virus-vectored vaccines are novel agents that can effectively activate specific and nonspecific immunity, are multivalent and multieffective, and have high safety ratings. Animal alphaherpesviruses have a large genome, contain multiple nonessential regions that do not affect viral replication and are capable of accepting the insertion of an exogenous gene and expressing the antigen protein. Furthermore, animal alphaherpesviruses have a wide host spectrum, can replicate in the host and continuously stimulate the animal to produce immunity to the corresponding pathogen, thus making them ideal carriers for recombinant virus-vectored vaccines. With the development of gene-editing technology, recombinant viruses capable of expressing foreign genes can be constructed by various methods. Currently, studies on recombinant virus-vectored vaccines constructed based on animal alphaherpesviruses have involved poultry, pigs, cattle, sheep, and companion animals. Studies have shown that the construction of recombinant animal alphaherpesviruses enables the acquisition of immunity to multiple diseases. This article mainly summarizes the current progress on animal alphaherpesvirus-vectored vaccines, aiming to provide reference for the development of new animal alphaherpesvirus-vectored vaccines.http://www.sciencedirect.com/science/article/pii/S2095311920631756recombinant vectored-vaccinerecombinant alphaherpesvirusesimmunitygene-editingexogenous gene |