Low dosage of histone H4 leads to growth defects and morphological changes in Candida albicans.

Low dosage of histone H4 leads to growth defects and morphological changes in Candida albicans.

Chromatin function depends on adequate histone stoichiometry. Alterations in histone dosage affect transcription and chromosome segregation, leading to growth defects and aneuploidies. In the fungal pathogen Candida albicans, aneuploidy formation is associated with antifungal resistance and pathogen...

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Bibliographic Details
Main Authors: Lucia F Zacchi, Anna M Selmecki, Judith Berman, Dana A Davis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2869362?pdf=render

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