Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy
Platelet-rich plasma (PRP), a blood derivative with high concentrations of platelets, has been found to have high levels of autologous growth factors (GFs), such as transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), fibroblastic growth factor (FGF), vascular endothelial gro...
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Online Access: | http://dx.doi.org/10.1155/2014/249498 |
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doaj-e44679d5ca09493991bc3de3510c94182020-11-25T01:09:22ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/249498249498Clinical Applications of Platelet-Rich Plasma in Patellar TendinopathyD. U. Jeong0C.-R. Lee1J. H. Lee2J. Pak3L.-W. Kang4B. C. Jeong5S. H. Lee6School of Medicine, Korea University College of Medicine, 73 Inchon-ro, Seongbuk-gu, Seoul 136-705, Republic of KoreaNational Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongji-ro, Yongin, Gyeonggi-do 449-728, Republic of KoreaNational Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongji-ro, Yongin, Gyeonggi-do 449-728, Republic of KoreaStems Medical Clinic, 32-3 Chungdam-dong, Gangnam-gu, Seoul 135-950, Republic of KoreaDepartment of Biological Sciences, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of KoreaNational Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongji-ro, Yongin, Gyeonggi-do 449-728, Republic of KoreaNational Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongji-ro, Yongin, Gyeonggi-do 449-728, Republic of KoreaPlatelet-rich plasma (PRP), a blood derivative with high concentrations of platelets, has been found to have high levels of autologous growth factors (GFs), such as transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), fibroblastic growth factor (FGF), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). These GFs and other biological active proteins of PRP can promote tissue healing through the regulation of fibrosis and angiogenesis. Moreover, PRP is considered to be safe due to its autologous nature and long-term usage without any reported major complications. Therefore, PRP therapy could be an option in treating overused tendon damage such as chronic tendinopathy. Here, we present a systematic review highlighting the clinical effectiveness of PRP injection therapy in patellar tendinopathy, which is a major cause of athletes to retire from their respective careers.http://dx.doi.org/10.1155/2014/249498 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
D. U. Jeong C.-R. Lee J. H. Lee J. Pak L.-W. Kang B. C. Jeong S. H. Lee |
spellingShingle |
D. U. Jeong C.-R. Lee J. H. Lee J. Pak L.-W. Kang B. C. Jeong S. H. Lee Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy BioMed Research International |
author_facet |
D. U. Jeong C.-R. Lee J. H. Lee J. Pak L.-W. Kang B. C. Jeong S. H. Lee |
author_sort |
D. U. Jeong |
title |
Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy |
title_short |
Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy |
title_full |
Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy |
title_fullStr |
Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy |
title_full_unstemmed |
Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy |
title_sort |
clinical applications of platelet-rich plasma in patellar tendinopathy |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Platelet-rich plasma (PRP), a blood derivative with high concentrations of platelets, has been found to have high levels of autologous growth factors (GFs), such as transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), fibroblastic growth factor (FGF), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). These GFs and other biological active proteins of PRP can promote tissue healing through the regulation of fibrosis and angiogenesis. Moreover, PRP is considered to be safe due to its autologous nature and long-term usage without any reported major complications. Therefore, PRP therapy could be an option in treating overused tendon damage such as chronic tendinopathy. Here, we present a systematic review highlighting the clinical effectiveness of PRP injection therapy in patellar tendinopathy, which is a major cause of athletes to retire from their respective careers. |
url |
http://dx.doi.org/10.1155/2014/249498 |
work_keys_str_mv |
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1725179232314720256 |