Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis
Neurotrophins constitute a family of growth factors initially characterized as predominant mediators of nervous system development, neuronal survival, regeneration and plasticity. Their biological activity is promoted by the binding of two different types of receptors, leading to the generation of m...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-05-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/11/5692 |
id |
doaj-e4518e655c02486082522f2caf3a98ce |
---|---|
record_format |
Article |
spelling |
doaj-e4518e655c02486082522f2caf3a98ce2021-06-01T01:14:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01225692569210.3390/ijms22115692Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol HomeostasisMayra Colardo0Noemi Martella1Daniele Pensabene2Silvia Siteni3Sabrina Di Bartolomeo4Valentina Pallottini5Marco Segatto6Department of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, 86090 Pesche, ItalyDepartment of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, 86090 Pesche, ItalyDepartment of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, 86090 Pesche, ItalyDepartment of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USADepartment of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, 86090 Pesche, ItalyDepartment of Science, University Roma Tre, Viale Marconi 446, 00146 Rome, ItalyDepartment of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, 86090 Pesche, ItalyNeurotrophins constitute a family of growth factors initially characterized as predominant mediators of nervous system development, neuronal survival, regeneration and plasticity. Their biological activity is promoted by the binding of two different types of receptors, leading to the generation of multiple and variegated signaling cascades in the target cells. Increasing evidence indicates that neurotrophins are also emerging as crucial regulators of metabolic processes in both neuronal and non-neuronal cells. In this context, it has been reported that neurotrophins affect redox balance, autophagy, glucose homeostasis and energy expenditure. Additionally, the trophic support provided by these secreted factors may involve the regulation of cholesterol metabolism. In this review, we examine the neurotrophins’ signaling pathways and their effects on metabolism by critically discussing the most up-to-date information. In particular, we gather experimental evidence demonstrating the impact of these growth factors on cholesterol metabolism.https://www.mdpi.com/1422-0067/22/11/5692BDNFcholesterolmetabolismneurotrophinsNGFp75NTR |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mayra Colardo Noemi Martella Daniele Pensabene Silvia Siteni Sabrina Di Bartolomeo Valentina Pallottini Marco Segatto |
spellingShingle |
Mayra Colardo Noemi Martella Daniele Pensabene Silvia Siteni Sabrina Di Bartolomeo Valentina Pallottini Marco Segatto Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis International Journal of Molecular Sciences BDNF cholesterol metabolism neurotrophins NGF p75NTR |
author_facet |
Mayra Colardo Noemi Martella Daniele Pensabene Silvia Siteni Sabrina Di Bartolomeo Valentina Pallottini Marco Segatto |
author_sort |
Mayra Colardo |
title |
Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis |
title_short |
Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis |
title_full |
Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis |
title_fullStr |
Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis |
title_full_unstemmed |
Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis |
title_sort |
neurotrophins as key regulators of cell metabolism: implications for cholesterol homeostasis |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-05-01 |
description |
Neurotrophins constitute a family of growth factors initially characterized as predominant mediators of nervous system development, neuronal survival, regeneration and plasticity. Their biological activity is promoted by the binding of two different types of receptors, leading to the generation of multiple and variegated signaling cascades in the target cells. Increasing evidence indicates that neurotrophins are also emerging as crucial regulators of metabolic processes in both neuronal and non-neuronal cells. In this context, it has been reported that neurotrophins affect redox balance, autophagy, glucose homeostasis and energy expenditure. Additionally, the trophic support provided by these secreted factors may involve the regulation of cholesterol metabolism. In this review, we examine the neurotrophins’ signaling pathways and their effects on metabolism by critically discussing the most up-to-date information. In particular, we gather experimental evidence demonstrating the impact of these growth factors on cholesterol metabolism. |
topic |
BDNF cholesterol metabolism neurotrophins NGF p75NTR |
url |
https://www.mdpi.com/1422-0067/22/11/5692 |
work_keys_str_mv |
AT mayracolardo neurotrophinsaskeyregulatorsofcellmetabolismimplicationsforcholesterolhomeostasis AT noemimartella neurotrophinsaskeyregulatorsofcellmetabolismimplicationsforcholesterolhomeostasis AT danielepensabene neurotrophinsaskeyregulatorsofcellmetabolismimplicationsforcholesterolhomeostasis AT silviasiteni neurotrophinsaskeyregulatorsofcellmetabolismimplicationsforcholesterolhomeostasis AT sabrinadibartolomeo neurotrophinsaskeyregulatorsofcellmetabolismimplicationsforcholesterolhomeostasis AT valentinapallottini neurotrophinsaskeyregulatorsofcellmetabolismimplicationsforcholesterolhomeostasis AT marcosegatto neurotrophinsaskeyregulatorsofcellmetabolismimplicationsforcholesterolhomeostasis |
_version_ |
1721412818113134592 |