TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS

TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS

Molecular mechanisms underlying neurodegenerative diseases converge at the interface of pathways impacting cellular stress, protein homeostasis and aging. Targeting the intrinsic capacities of neuroprotective proteins to restore neuronal function and/or attenuate degeneration represents a potential...

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Bibliographic Details
Main Authors: Michelle L. Thompson, Pan Chen, Xiaohui Yan, Hanna Kim, Akeem R. Borom, Nathan B. Roberts, Kim A. Caldwell, Guy A. Caldwell
Format: Article
Language:English
Published: The Company of Biologists 2014-02-01
Series:Disease Models & Mechanisms
Subjects:
ALS
ER stress
Chaperone
Neurotransmission
TorsinA
Online Access:http://dmm.biologists.org/content/7/2/233

Internet

http://dmm.biologists.org/content/7/2/233

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