Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo
How the cardiac myocyte epigenome is rearranged during development, postnatal maturation and disease is not well understood. Here, the authors investigate the human cardiac myocyte epigenome during development and chronic heart failure and identify distinct epigenetic programs regulating these proce...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02762-z |
| id |
doaj-e46b79bc29434dea9a7d59690c85ee94 |
|---|---|
| record_format |
Article |
| spelling |
doaj-e46b79bc29434dea9a7d59690c85ee942021-05-11T10:04:43ZengNature Publishing GroupNature Communications2041-17232018-01-019111410.1038/s41467-017-02762-zDistinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivoRalf Gilsbach0Martin Schwaderer1Sebastian Preissl2Björn A. Grüning3David Kranzhöfer4Pedro Schneider5Thomas G. Nührenberg6Sonia Mulero-Navarro7Dieter Weichenhan8Christian Braun9Martina Dreßen10Adam R. Jacobs11Harald Lahm12Torsten Doenst13Rolf Backofen14Markus Krane15Bruce D. Gelb16Lutz Hein17Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of FreiburgInstitute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of FreiburgInstitute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of FreiburgBioinformatics Group, Department of Computer Science, University of FreiburgInstitute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of FreiburgInstitute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of FreiburgInstitute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of FreiburgThe Mindich Child Health and Development Institute, Icahn School of Medicine at Mount SinaiEpigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ)Forensic Institute, Ludwig-Maximilians-UniversityDepartment of Cardiovascular Surgery, German Heart Center, Technische Universität MünchenDepartment of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount SinaiDepartment of Cardiovascular Surgery, German Heart Center, Technische Universität MünchenDepartment of Cardiothoracic Surgery, Jena University Hospital, Friedrich-Schiller-UniversityBioinformatics Group, Department of Computer Science, University of FreiburgDepartment of Cardiovascular Surgery, German Heart Center, Technische Universität MünchenThe Mindich Child Health and Development Institute, Icahn School of Medicine at Mount SinaiInstitute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of FreiburgHow the cardiac myocyte epigenome is rearranged during development, postnatal maturation and disease is not well understood. Here, the authors investigate the human cardiac myocyte epigenome during development and chronic heart failure and identify distinct epigenetic programs regulating these processes.https://doi.org/10.1038/s41467-017-02762-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ralf Gilsbach Martin Schwaderer Sebastian Preissl Björn A. Grüning David Kranzhöfer Pedro Schneider Thomas G. Nührenberg Sonia Mulero-Navarro Dieter Weichenhan Christian Braun Martina Dreßen Adam R. Jacobs Harald Lahm Torsten Doenst Rolf Backofen Markus Krane Bruce D. Gelb Lutz Hein |
| spellingShingle |
Ralf Gilsbach Martin Schwaderer Sebastian Preissl Björn A. Grüning David Kranzhöfer Pedro Schneider Thomas G. Nührenberg Sonia Mulero-Navarro Dieter Weichenhan Christian Braun Martina Dreßen Adam R. Jacobs Harald Lahm Torsten Doenst Rolf Backofen Markus Krane Bruce D. Gelb Lutz Hein Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo Nature Communications |
| author_facet |
Ralf Gilsbach Martin Schwaderer Sebastian Preissl Björn A. Grüning David Kranzhöfer Pedro Schneider Thomas G. Nührenberg Sonia Mulero-Navarro Dieter Weichenhan Christian Braun Martina Dreßen Adam R. Jacobs Harald Lahm Torsten Doenst Rolf Backofen Markus Krane Bruce D. Gelb Lutz Hein |
| author_sort |
Ralf Gilsbach |
| title |
Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo |
| title_short |
Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo |
| title_full |
Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo |
| title_fullStr |
Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo |
| title_full_unstemmed |
Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo |
| title_sort |
distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-01-01 |
| description |
How the cardiac myocyte epigenome is rearranged during development, postnatal maturation and disease is not well understood. Here, the authors investigate the human cardiac myocyte epigenome during development and chronic heart failure and identify distinct epigenetic programs regulating these processes. |
| url |
https://doi.org/10.1038/s41467-017-02762-z |
| work_keys_str_mv |
AT ralfgilsbach distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT martinschwaderer distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT sebastianpreissl distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT bjornagruning distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT davidkranzhofer distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT pedroschneider distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT thomasgnuhrenberg distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT soniamuleronavarro distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT dieterweichenhan distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT christianbraun distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT martinadreßen distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT adamrjacobs distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT haraldlahm distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT torstendoenst distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT rolfbackofen distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT markuskrane distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT brucedgelb distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo AT lutzhein distinctepigeneticprogramsregulatecardiacmyocytedevelopmentanddiseaseinthehumanheartinvivo |
| _version_ |
1721448778281517056 |