Neutrophilic Asthma Is Associated With Smoking, High Numbers of IRF5+, and Low Numbers of IL10+ Macrophages

Neutrophilic Asthma Is Associated With Smoking, High Numbers of IRF5+, and Low Numbers of IL10+ Macrophages

Asthma is a heterogenous disease with different inflammatory subgroups that differ in disease severity. This disease variation is hampering treatment and development of new treatment strategies. Macrophages may contribute to asthma phenotypes by their ability to activate in different ways, i.e., T h...

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Bibliographic Details
Main Authors: Nil Turan, T. Anienke van der Veen, Christina Draijer, Fatemeh Fattahi, Nick H. ten Hacken, Wim Timens, Antoon J. van Oosterhout, Maarten van den Berge, Barbro N. Melgert
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Allergy
Subjects:
biopsy
inflammatory endotypes
macrophages subtypes
FEV1
CD206
M1
Online Access:https://www.frontiersin.org/articles/10.3389/falgy.2021.676930/full

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