Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans
Summary: Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human aging and disease. Thus far, it has proven difficult to develop successful treatment strategies for diseases that are caused by mtDNA instability. To address this issue, we developed a model of mtDNA di...
Main Authors: | Suraiya Haroon, Annie Li, Jaye L. Weinert, Clark Fritsch, Nolan G. Ericson, Jasmine Alexander-Floyd, Bart P. Braeckman, Cole M. Haynes, Jason H. Bielas, Tali Gidalevitz, Marc Vermulst |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2018-03-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124718303097 |
Similar Items
-
Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans
by: J. Alexander-Floyd, et al.
Published: (2020-02-01) -
Ancient mtDNA genetic variants modulate mtDNA transcription and replication.
by: Sarit Suissa, et al.
Published: (2009-05-01) -
Melanesian mtDNA complexity.
by: Jonathan S Friedlaender, et al.
Published: (2007-01-01) -
Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy
by: Florence van Tienen, et al.
Published: (2019-12-01) -
Origins and evolution of the Etruscans' mtDNA.
by: Silvia Ghirotto, et al.
Published: (2013-01-01)